Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Institute, The University of Melbourne, Melbourne, Victoria, Australia.
Microbeam Laboratory, CSIRO Mineral Resources, Clayton, Victoria, Australia.
Sci Rep. 2019 Feb 4;9(1):1285. doi: 10.1038/s41598-018-37580-w.
Dental caries, erosion and hypersensitivity are major public health problems. SnF is used widely in oral care products to help prevent/treat these conditions. Casein phosphopeptide-stabilised amorphous calcium phosphate nanocomplexes (CPP-ACP) are a biomimetic nanotechnology of salivary phosphopeptide-ACP complexes that deliver bioavailable calcium and phosphate ions to promote dental remineralisation (repair). We show here using in vitro studies and a double-blind, randomised controlled, cross-over design in situ clinical trial that SnF and CPP-ACP interact to form a nanofilament coating on the tooth surface and that together they are superior in their ability to promote dental remineralisation. Sn(II) by cross-linking the CPP-ACP helps to stabilise the complexes which improves delivery to the tooth surface and enhances binding and ion incorporation into tooth mineral. The combination of SnF and CPP-ACP in oral care products may significantly improve their efficacy in prevention/treatment of dental caries/erosion and hypersensitivity.
龋齿、酸蚀症和牙齿敏感是主要的公共卫生问题。SnF 被广泛应用于口腔护理产品中，以帮助预防/治疗这些病症。酪蛋白磷酸肽稳定的无定形磷酸钙纳米复合物（CPP-ACP）是一种仿生纳米技术，模拟了唾液磷蛋白-ACP 复合物，可提供生物可利用的钙和磷酸盐离子，促进牙齿再矿化（修复）。我们通过体外研究和一项双盲、随机、交叉设计的体内临床试验表明，SnF 和 CPP-ACP 相互作用，在牙齿表面形成纳米纤维涂层，而且它们在促进牙齿再矿化方面的能力更优。Sn(II) 通过交联 CPP-ACP 有助于稳定复合物，从而改善其向牙齿表面的输送，并增强与牙体矿物的结合和离子掺入。将 SnF 和 CPP-ACP 结合在口腔护理产品中，可能会显著提高其在预防/治疗龋齿/酸蚀症和牙齿敏感方面的功效。
