Department of Emergency and Critical Care Medicine, Keio University School of Medicine, Tokyo, Japan.
Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Sci Rep. 2019 Feb 4;9(1):1255. doi: 10.1038/s41598-018-38180-4.
Hydrogen has therapeutic and preventive effects against various diseases. Although animal and clinical studies have reported promising results, hydrogen distribution in organs after administration remains unclear. Herein, the sequential changes in hydrogen concentration in tissues over time were monitored using a highly sensitive glass microsensor and continuous inhalation of 3% hydrogen gas. The hydrogen concentration was measured in the brain, liver, kidney, mesentery fat and thigh muscle of rats. The maximum concentration, time to saturation, and other measurements representing the dynamics of distribution were obtained from the concentration curves, and the results obtained for different organs were compared. The time to saturation was significantly longer (20.2 vs 6.3-9.4 min. P = 0.004 in all cases) and increased more gradually in muscle than in the other organs. The maximum concentration was the highest in liver and the lowest in the kidney (29.0 ± 2.6 vs 18.0 ± 2.2 μmol/L; P = 0.03 in all cases). The concentration varied significantly depending on the organ (P = 0.03). These results provide the fundamentals for elucidating the mechanisms underlying the in vivo favourable effects of hydrogen gas in mammalian systems.
氢气对多种疾病具有治疗和预防作用。尽管动物和临床研究已经报告了有希望的结果，但氢在给药后在器官中的分布仍不清楚。在此，使用高灵敏度的玻璃微传感器和连续吸入 3%氢气来监测组织中氢气浓度随时间的顺序变化。测量了大鼠脑、肝、肾、肠系膜脂肪和大腿肌肉中的氢气浓度。从浓度曲线中获得了代表分布动态的最大浓度、饱和时间和其他测量值，并比较了不同器官的结果。饱和时间在肌肉中明显更长（20.2 与 6.3-9.4 min，所有情况均 P=0.004），且分布更渐进。肝脏中的最大浓度最高，肾脏中的最低（29.0±2.6 与 18.0±2.2 μmol/L；所有情况均 P=0.03）。浓度根据器官而有显著差异（P=0.03）。这些结果为阐明氢气在哺乳动物系统中体内有利作用的机制提供了基础。
