Alvarado-Esquivel Cosme, Sánchez-Anguiano Luis Francisco, Hernández-Tinoco Jesús, Ramos-Nevarez Agar, Estrada-Martínez Sergio, Cerrillo-Soto Sandra Margarita, Mijarez-Hernández Miriam Alejandra, Guido-Arreola Carlos Alberto, Pérez-Álamos Alma Rosa, Beristain-Garcia Isabel, Rábago-Sánchez Elizabeth
Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico.
Institute for Scientific Research "Dr. Roberto Rivera-Damm ", Juárez University of Durango State, Avenida Universidad S/N, 34000 Durango, Mexico.
Eur J Microbiol Immunol (Bp). 2018 Nov 15;8(4):155-158. doi: 10.1556/1886.2018.00021. eCollection 2018 Dec 23.
We determined the association between having a history of surgery and the seroreactivity to An age- and gender-matched case-control study of 391 subjects with a history of surgery and 391 subjects without this history was performed. Sera of subjects were analyzed for detection of anti- immunoglobulin G (IgG) and M (IgM) antibodies using enzyme-linked immunoassays. Anti- IgG antibodies were found in 25 (6.4%) of the 391 cases and in 21 (5.4%) of the 391 controls (odds ratio [OR] = 1.29; 95% confidence interval [CI]: 0.66-2.18; = 0.54). The frequency of cases with high IgG antibody levels (10/25: 40.0%) was equal to that found in controls (8/21: 38.1%) (OR = 1.08; 95% CI: 0.32-3.56; = 0.89). Of the 25 anti- IgG antibody seropositive cases, 5 (16.0%) were also positive for anti IgM antibodies. Meanwhile, of the 21 anti IgG antibody seropositive controls, 4 (19.0%) were also positive for anti-T IgM antibodies (OR = 0.81; 95% CI: 0.17-3.72; = 0.80). Logistic regression showed that only the variable "hysterectomy" was associated with seropositivity (OR = 4.6; 95% CI: 1.6-13.4; = 0.005). Results suggest that having a history of surgery is not an important risk factor for infection with However, the link between infection and hysterectomy should be further investigated.
我们确定了手术史与对[病原体名称未给出]血清反应性之间的关联。对391例有手术史的受试者和391例无此病史的受试者进行了年龄和性别匹配的病例对照研究。使用酶联免疫吸附测定法分析受试者血清，以检测抗[病原体名称未给出]免疫球蛋白G（IgG）和M（IgM）抗体。在391例病例中有25例（6.4%）检测到抗[病原体名称未给出]IgG抗体，在391例对照中有21例（5.4%）检测到（比值比[OR]=1.29；95%置信区间[CI]：0.66 - 2.18；P=0.54）。高IgG抗体水平病例的频率（10/25：40.0%）与对照中发现的频率（8/21：38.1%）相等（OR = 1.08；95% CI：0.32 - 3.56；P = 0.89）。在25例抗[病原体名称未给出]IgG抗体血清阳性病例中，5例（16.0%）抗IgM抗体也呈阳性。同时，在21例抗[病原体名称未给出]IgG抗体血清阳性对照中，4例（19.0%）抗[病原体名称未给出]IgM抗体也呈阳性（OR = 0.81；95% CI：0.17 - 3.72；P = 0.80）。逻辑回归显示，只有“子宫切除术”这一变量与血清阳性相关（OR = 4.6；95% CI：1.6 - 13.4；P = 0.005）。结果表明，有手术史并非感染[病原体名称未给出]的重要危险因素。然而，[病原体名称未给出]感染与子宫切除术之间的联系应进一步研究。
