Drexel University, School of Biomedical Engineering, Science and Health Systems, Philadelphia, Penns, United States.
University of Pennsylvania, Department of Family and Community Health, Philadelphia, Pennsylvania, United States.
J Biomed Opt. 2019 Feb;24(5):1-10. doi: 10.1117/1.JBO.24.5.051411.
Timing of the intervention for intracranial hematomas is critical for its success, specifically since expansion of the hemorrhage can result in debilitating and sometimes fatal outcomes. Led by Britton Chance, we and an extended team from University of Pennsylvania, Baylor and Drexel universities developed a handheld brain hematoma detector for early triage and diagnosis of head trauma victims. After obtaining de novo Food and Drug Administration clearance, over 200 systems are deployed in all Marine battalion aid stations around the world. Infrascanner, a handheld brain hematoma detection system, is based on the differential near-infrared light absorption of the injured versus the noninjured part of brain. About 12 independent studies have been conducted in the USA, Canada, Spain, Italy, the Netherlands, Germany, Russia, Poland, Afghanistan, India, China, and Turkey. Here, we outline the background and design of the device as well as clinical studies with a total of 1293 patients and 203 hematomas. Infrascanner demonstrates high sensitivity (adults: 92.5% and children: 93%) and specificity (adults: 82.9% and children: 86.5%) in detecting intracranial hematomas >3.5 mL in volume and <2.5 cm from the surface of the brain. Infrascanner is a clinically effective screening solution for head trauma patients in prehospital settings where timely triage is critical.
颅内血肿干预的时机对其成功至关重要，特别是因为出血的扩大可能导致衰弱甚至有时致命的后果。在 Britton Chance 的带领下，我们和宾夕法尼亚大学、贝勒大学和德雷克塞尔大学的一个扩展团队一起开发了一种手持式脑血肿探测器，用于对头部创伤患者进行早期分诊和诊断。在获得新的食品和药物管理局批准后，全球有 200 多个系统部署在所有海军营救护站。手持式脑血肿检测系统 Infrascanner 基于受伤和未受伤脑组织对近红外光的差异吸收。在美国、加拿大、西班牙、意大利、荷兰、德国、俄罗斯、波兰、阿富汗、印度、中国和土耳其进行了大约 12 项独立研究。在这里，我们概述了该设备的背景和设计以及总共 1293 名患者和 203 个血肿的临床研究。Infrascanner 在检测体积>3.5 毫升且距大脑表面<2.5 厘米的颅内血肿方面具有很高的灵敏度（成人：92.5%，儿童：93%）和特异性（成人：82.9%，儿童：86.5%）。Infrascanner 是一种在创伤现场至关重要的情况下对头部创伤患者进行有效筛选的临床解决方案。
