Angle Orthod. 2019 May;89(3):365-371. doi: 10.2319/051818-371.1. Epub 2019 Feb 5.
To determine the effect of Clinpro 5000, Clinpro Tooth Crème, and MI-Paste Plus on the formation of white spot lesions in patients undergoing orthodontic treatment.
Three prospective groups with 40 patients undergoing orthodontic treatment in each group were evaluated (total recruitment = 120 subjects). The selected product was brushed on for 2 minutes twice daily for 4 months. Subjects were reviewed for 4 months on a monthly basis. The Enamel Decalcification Index (EDI) was used to determine the number of white spot lesions per surface at each visit.
100 subjects (35 using Clinpro 5000, 32 using Clinpro Tooth Crème, and 33 using MI Paste Plus) completed the study. The data lend strong support for Clinpro 5000 providing superior protection against enamel decalcification when compared to Clinpro Crème, and mixed support when compared to MI Paste Plus.
The use of Clinpro 5000, Clinpro Crème, and MI paste Plus all have a reduction effect on white spot lesions when compared to studies reported previously. Clinpro 5000 has a marginally better effect than the two other test pastes. The results of this study can be used by clinicians when deciding the effectiveness of using fluoride dentifrice products to prevent white spot lesions in their orthodontic practice (ClinicalTrials.gov ID: NCT03440996).
确定 Clinpro 5000、Clinpro 牙膏和 MI-Paste Plus 对正畸治疗患者中白斑形成的影响。
评估了三个前瞻性组，每组 40 名正在接受正畸治疗的患者（总招募人数=120 名受试者）。选择的产品每天刷牙两次，每次 2 分钟，持续 4 个月。每月对受试者进行 4 个月的复查。使用牙釉质脱矿指数（EDI）在每次就诊时确定每个表面的白斑数量。
100 名受试者（35 名使用 Clinpro 5000、32 名使用 Clinpro 牙膏、33 名使用 MI 糊剂）完成了研究。数据强烈支持 Clinpro 5000 与 Clinpro 牙膏相比，对牙釉质脱矿具有更好的保护作用，与 MI 糊剂相比，支持作用混合。
与以前报告的研究相比，使用 Clinpro 5000、Clinpro 牙膏和 MI 糊剂都对白斑有减少作用。Clinpro 5000 的效果略优于另外两种测试糊剂。本研究的结果可用于临床医生在决定使用含氟牙膏产品预防正畸治疗中白斑的有效性时参考（ClinicalTrials.gov ID：NCT03440996）。
