Department of Pediatric Dentistry, Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Av. do Café, s/nº, Monte Alegre, 14040-904, Ribeirão Preto, Brazil.
Department of Dental Materials and Prosthodontics, Faculty of Dentistry of Ribeirao Preto, University of São Paulo, Av. do Cafe, s/nº, Monte Alegre, 14040-904, Ribeirão Preto, Brazil.
Clin Oral Investig. 2022 Sep;26(9):5885-5892. doi: 10.1007/s00784-022-04546-2. Epub 2022 May 19.
Radiotherapy (RT) is a kind of head and neck cancer (HNC) treatment, which is associated to the habit of smoking and can develop collateral effects in the oral cavity, such as the increase of caries prevalence. This study evaluated the color alteration, the microhardness, and the remineralizing potential of high fluoride concentration toothpastes on irradiated teeth.
Forty bovine teeth were used (6 × 6 × 2 mm) and after color (EasyShade, VITA) and microhardness initial readings were separated into two groups: exposed to cigarette smoke and non-exposed. All samples were submitted to RT (30 Gy) and to cariogenic challenge. New color and microhardness readings were done. After RT (60 Gy), the samples were submitted to simulated toothbrushing (73,000 cycles = 5 years of brushing) with two different toothpastes: conventional (1450 ppm) and high fluoride concentration (5000 ppm). Final color and microhardness readings were done after brushing. Data were analyzed with 2-way ANOVA with repeated measures and Tukey's test (p < .05).
There was no color difference after RT, nor after brushing (p > .05). However, after brushing, microhardness values increased for the samples treated with high fluoride concentration toothpaste (p < .05).
Radiotherapy did not influence the teeth color, and the high fluoride concentration toothpaste presented remineralizing potential; therefore, it could be used on the caries prevention related to HNC radiation.
Considering its remineralizing potential, toothpastes with high fluoride concentration could be a proper alternative for caries prevention in patients undergoing radiotherapy.
放射治疗（RT）是一种头颈部癌症（HNC）的治疗方法，它与吸烟习惯有关，并可能在口腔中产生副作用，例如龋齿患病率增加。本研究评估了高氟浓度牙膏对放射治疗牙齿的颜色改变、显微硬度和再矿化潜力。
使用 40 颗牛牙（6×6×2mm），在进行颜色（EasyShade，VITA）和初始显微硬度读数之前，将其分为两组：暴露于香烟烟雾和未暴露于香烟烟雾。所有样本均接受 RT（30Gy）和致龋挑战。进行新的颜色和显微硬度读数。在 RT（60Gy）后，用两种不同的牙膏对样本进行模拟刷牙（73000 次循环=5 年刷牙）：常规牙膏（1450ppm）和高氟浓度牙膏（5000ppm）。刷牙后进行最终的颜色和显微硬度读数。数据采用双向方差分析和重复测量的 Tukey 检验进行分析（p<.05）。
RT 后和刷牙后牙齿颜色均无差异（p>.05）。然而，刷牙后，用高氟浓度牙膏处理的样本显微硬度值增加（p<.05）。
放射治疗不会影响牙齿颜色，高氟浓度牙膏具有再矿化潜力；因此，它可用于预防与 HNC 放射治疗相关的龋齿。
考虑到其再矿化潜力，高氟浓度牙膏可能是放射治疗患者预防龋齿的合适选择。
