Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, OX1 3TA, UK.
Department of Chemistry and Institute of Physics of Living Systems, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Angew Chem Int Ed Engl. 2019 Mar 26;58(14):4581-4586. doi: 10.1002/anie.201814320. Epub 2019 Feb 27.
The synthesis and aqueous self-assembly of a new class of amphiphilic aliphatic polyesters are presented. These AB block polyesters comprise polycaprolactone (hydrophobe) and an alternating polyester from succinic acid and an ether-substituted epoxide (hydrophile). They self-assemble into biodegradable polymersomes capable of entering cells. Their degradation products are bioactive, giving rise to differentiated cellular responses inducing stromal cell proliferation and macrophage apoptosis. Both effects emerge only when the copolymers enter cells as polymersomes and their magnitudes are size dependent.
本文介绍了一类新型两亲脂肪族聚酯的合成及其在水溶液中的自组装。这些 AB 嵌段聚酯由聚己内酯（疏水物）和琥珀酸与醚取代环氧化物的交替聚酯（亲水物）组成。它们自组装成可进入细胞的可生物降解聚合物囊泡。其降解产物具有生物活性，可引起细胞的分化反应，促进基质细胞增殖和巨噬细胞凋亡。只有当共聚物作为聚合物囊泡进入细胞时，才会出现这两种作用，并且其幅度与尺寸有关。
