Dennis J W
Department of Medical Genetics, University of Toronto, Ontario, Canada.
Cancer Surv. 1988;7(4):573-95.
There is now considerable evidence that malignant transformation is accompanied by many changes in the oligosaccharide structures of glycoproteins and glycolipids. More recently, studies using tumour cell glycosylation mutants and inhibitors of Asn-linked oligosaccharide processing have suggested that the transformation-associated increase in GlcNAc beta 1-6Man alpha 1-6 Man beta- branching of complex-type oligosaccharides may enhance tumour cell metastasis. The synthesis of beta 1-6 branched oligosaccharides and related structures as well as their possible function in cell-cell interactions and tumour cell metastasis are discussed.
现在有大量证据表明，恶性转化伴随着糖蛋白和糖脂寡糖结构的许多变化。最近，使用肿瘤细胞糖基化突变体和N-连接寡糖加工抑制剂的研究表明，复杂型寡糖中GlcNAcβ1-6Manα1-6Manβ分支与转化相关的增加可能会增强肿瘤细胞转移。本文讨论了β1-6分支寡糖及其相关结构的合成，以及它们在细胞间相互作用和肿瘤细胞转移中的可能功能。
