Department of Biotechnology, Quaid-i-Azam University Islamabad, Islamabad, 45000, Pakistan.
Department of Eastern Medicine and Surgery, Qarshi University, Lahore, Pakistan.
Appl Microbiol Biotechnol. 2019 Mar;103(6):2551-2569. doi: 10.1007/s00253-019-09661-x. Epub 2019 Feb 5.
Biosynthesis has emerged as a frontier technology for fabrication of functionally diverse nanoparticles that possess tremendous therapeutic implications. Various biological resources have already demonstrated their potential to produce nanoparticles with interesting features. Endophytic microbes live in a symbiotic relationship with plants possessing a unique and versatile reservoir of potentially therapeutic secondary metabolites having the tendency to reduce metallic ions into nanoparticles. Successful biosynthesis of AgNPs using endophytic organisms has already been reported; however, the overall picture about its synthesis and applications is still not clear. In the current article, a comprehensive review of literature was performed for comparing different physical and biological properties of endophytic microbe-derived AgNPs. In addition, the present paper mechanistically explains the synthesis of AgNPs and their diverse pharmacognostic properties. Further studies are encouraged to understand the mechanism of biopharmaceutical effects of these endophyte-mediated NPs.
生物合成已成为一种前沿技术，可用于制造具有多种功能的纳米粒子，这些纳米粒子具有巨大的治疗意义。各种生物资源已经证明了它们在生产具有有趣特性的纳米粒子方面的潜力。内生微生物与植物共生，植物拥有独特而多样的潜在治疗性次生代谢产物库，具有将金属离子还原成纳米粒子的趋势。已经有使用内生生物合成 AgNPs 的成功案例，但关于其合成和应用的全貌尚不清楚。在本文中，对文献进行了全面回顾，比较了内生微生物衍生的 AgNPs 的不同物理和生物学特性。此外，本文从机制上解释了 AgNPs 的合成及其多样化的药物特性。鼓励进一步研究以了解这些内生介导的 NPs 的生物制药作用的机制。
