Department of Geriatrics, Neurosciences and Orthopedics, Fondazione Policlinico Gemelli IRCCS, Roma, Italy.
Università Cattolica del Sacro Cuore, Roma, Italy.
Biomed Res Int. 2019 Jan 6;2019:1970878. doi: 10.1155/2019/1970878. eCollection 2019.
Nutritional approaches to improve dyslipidemias have been recently developed, but evidences on different medical foods are often incomplete. The main aim of our study was to evaluate the effects on endothelial function, lipid profile, and glucose metabolism of two different combinations of nutraceuticals, first one containing Bergavit (200 mg Citrus bergamia), Omega-3 (400 mg), Crominex 3+ (10 mcg trivalent chromium), and red yeast rice (100 mg; 5 mg monacolin K) and second one containing red yeast rice (200 mg; 3 mg monacolin K), Berberine (500 mg), Astaxanthin (0.5 mg), folic acid (200 mcg), Coenzyme Q10 (2 mg), and Policosanol (10 mg). Fifty subjects affected by dyslipidemia not requiring statin treatment were enrolled in this randomized, blind, controlled trial and submitted to blood sampling for lipid and glucose profiles and instrumental evaluation of endothelial function before and after 6 weeks of treatment with nutraceuticals. Both nutraceutical combinations improved the lipid profile; the nutraceutical containing 5 mg of monacolin K, 200 mg of the extract , 400 mg of Omega-3, and 10 mcg of trivalent chromium entailed a significant improvement of endothelial function with enhanced cholesterol lowering effect. In conclusion, this study confirms the positive effect of functional food on lipid profile and endothelial function in absence of major undesirable effects.
最近已经开发出了改善血脂异常的营养方法，但关于不同的医疗食品的证据往往不完整。我们研究的主要目的是评估两种不同的营养保健品组合对内皮功能、血脂谱和葡萄糖代谢的影响，第一种组合含有 Bergavit（200mg 佛手柑）、Omega-3（400mg）、Crominex 3+（10mcg 三价铬）和红曲米（100mg；5mg 洛伐他汀），第二种组合含有红曲米（200mg；3mg 洛伐他汀）、黄连素（500mg）、虾青素（0.5mg）、叶酸（200mcg）、辅酶 Q10（2mg）和聚乙二醇（10mg）。50 名患有血脂异常但不需要他汀类药物治疗的患者参加了这项随机、双盲、对照试验，并在接受营养保健品治疗 6 周前后进行了血脂和血糖谱的血液采样以及内皮功能的仪器评估。两种营养保健品组合均改善了血脂谱；含有 5mg 洛伐他汀、200mg 提取物、400mg Omega-3 和 10mcg 三价铬的营养保健品组合显著改善了内皮功能，同时降低了胆固醇。总之，这项研究证实了功能性食品对血脂谱和内皮功能的积极影响，同时没有产生重大不良影响。
