Hafez Hassanain Nawal Abdel, Shaapan Raafat Mohamed, Hafez Hassanain Mohey Abdel
Pak J Biol Sci. 2018 Jan;21(9):463-468. doi: 10.3923/pjbs.2018.463.468.
The major maternal toxoplasmosis infection during pregnancy is regularly related to trans-placental transmission to the embryo and newly-borne child. This cross-section study was performed to investigate the prevalence of toxoplasmosis among pregnant women attending antennal health centers.
The IgM antibodies against Toxoplasma were quantitatively determined by commercially available kits, while IgG antibodies and avidity (AV) of Toxoplasma gondii-specific IgG antibodies were quantitatively determined by using of conventional ELISA.
The overall seroprevalence of T. gondii IgM among the investigated pregnant women was much higher than toxoplasma IgG with low IgG avidity representing acute infection with possibility of risk to the mother, embryo and newly-borne child. Results also showed that highest Toxoplasma prevalence was among pregnant women with history of intake of immunosuppressive drugs and abortion, having cats and animals in their households and in the 1st and 2nd trimesters.
The high infection prevalence of T. gondii among the Egyptian pregnant women in Giza governorate revealed the risk of premature termination of pregnancy due to exposure of T. gondii infection.
孕期母亲弓形虫主要感染通常与经胎盘传播给胚胎和新生儿有关。本横断面研究旨在调查在产前保健中心就诊的孕妇中弓形虫病的患病率。
采用市售试剂盒定量检测抗弓形虫IgM抗体，同时采用传统酶联免疫吸附测定法（ELISA）定量检测弓形虫特异性IgG抗体及其亲和力（AV）。
在所调查的孕妇中，弓形虫IgM的总体血清阳性率远高于弓形虫IgG，低IgG亲和力代表急性感染，可能对母亲、胚胎和新生儿构成风险。结果还显示，弓形虫患病率最高的是有免疫抑制药物摄入史和流产史、家中养猫和其他动物以及处于妊娠第一和第二孕期的孕妇。
吉萨省埃及孕妇中弓形虫感染率较高，这表明由于接触弓形虫感染存在妊娠提前终止的风险。
