College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, Jilin, P. R. China.
Food Funct. 2019 Feb 20;10(2):1159-1166. doi: 10.1039/c8fo02558d.
Herein, Athelia rolfsii exopolysaccharides (AEPS) were used to alleviate organ damage in lead-exposed mice. Analysis of the body weight growth rate and visceral index revealed that AEPS maintained the normal body weight growth rates in lead-exposed mice. Biochemical indicators (T-SOD, CAT, MDA) in serum revealed that AEPS increased the activity of T-SOD in the serum of lead-exposed mice. The lead concentrations in the brain, liver, kidneys, testis and faeces were measured by flame atomic absorption. The percent reductions in lead accumulation in these organs were 76.65% (brain), 60.42% (liver), 78.43% (kidneys) and 56.47% (testis). The data suggest that a significant portion of the lead was expelled in the faeces. The results proved that AEPS prevented lead accumulation in the organs of lead-exposed mice. A histological evaluation of the brain, liver, kidneys and testis also revealed that AEPS significantly alleviated liver and kidney damage caused by lead poisoning and protected neurons and sperm cells. We hypothesize that the ingested AEPS chelated the lead in the digestive system of the mice, leading to excretion through the faeces. Thus, AEPS represent a promising method of detoxification following lead poisoning.
本文使用卷枝毛霉胞外多糖（AEPS）来缓解铅暴露小鼠的器官损伤。分析体重增长率和内脏指数表明，AEPS 维持了铅暴露小鼠的正常体重增长率。血清中的生化指标（T-SOD、CAT、MDA）表明，AEPS 提高了铅暴露小鼠血清中 T-SOD 的活性。通过火焰原子吸收法测定了脑组织、肝脏、肾脏、睾丸和粪便中的铅浓度。这些器官中铅积累减少的百分比分别为 76.65%（大脑）、60.42%（肝脏）、78.43%（肾脏）和 56.47%（睾丸）。数据表明，大部分铅被排泄到粪便中。结果证明 AEPS 可防止铅在铅暴露小鼠的器官中积累。对大脑、肝脏、肾脏和睾丸的组织学评估还表明，AEPS 显著缓解了铅中毒引起的肝和肾损伤，并保护了神经元和精子细胞。我们假设摄入的 AEPS 螯合了小鼠消化系统中的铅，导致通过粪便排出。因此，AEPS 代表了一种有前途的铅中毒解毒方法。
