Witney Timothy H, Lewis David Y
Imaging Chemistry and Biology, King's College London, London, UK.
Molecular Imaging Laboratory, Cancer Research UK Beatson Institute, Glasgow, UK.
Methods Mol Biol. 2019;1928:29-44. doi: 10.1007/978-1-4939-9027-6_2.
Positron emission tomography (PET) enables the noninvasive spatiotemporal analysis of cancer metabolism in vivo. Both natural and nonnatural PET tracers have been developed to assess metabolic pathways during tumorigenesis, cancer progression, and metastasis. Here we describe the dynamic in vivo PET/CT imaging of the glucose analogue [F]fluoro-2-deoxy-D-glucose (FDG), taking into consideration the methodology for alternative metabolic PET substrates.
正电子发射断层扫描（PET）能够在体内对癌症代谢进行无创的时空分析。天然和非天然的PET示踪剂均已被开发出来，用于评估肿瘤发生、癌症进展和转移过程中的代谢途径。在此，我们描述了葡萄糖类似物[F]氟-2-脱氧-D-葡萄糖（FDG）的动态体内PET/CT成像，并考虑了替代代谢PET底物的方法。
