Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan 030001, China.
Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China.
Cancer Biol Med. 2020 May 15;17(2):307-327. doi: 10.20892/j.issn.2095-3941.2020.0072.
Colorectal cancer (CRC) is the most common gastrointestinal tract cancer worldwide and is associated with high morbidity and mortality. The development of nanosized drug delivery systems has provided a new direction in CRC treatment. Among these systems, magnetic nanoparticle (MNP)-based multifunctional platforms provide a novel strategy for magnetic resonance imaging (MRI)-related cancer theranostics. At the beginning of this original review, the carcinogenesis and treatment status of CRC are summarized. Then, diversified preparation and functionalization methods of MNPs are systematically analyzed, followed by MRI-involved theranostic strategies. The latest progress in MRI-mediated multimode diagnosis and image-guided targeted therapy in CRC management is the main focus. Finally, the major challenges in promoting MRI-induced precise theranostics of CRC in clinical practice are discussed.
结直肠癌（CRC）是全球最常见的胃肠道癌，发病率和死亡率都很高。纳米药物递送系统的发展为 CRC 的治疗提供了新的方向。在这些系统中，基于磁性纳米颗粒（MNP）的多功能平台为与磁共振成像（MRI）相关的癌症治疗学提供了一种新策略。在这篇综述的开始，总结了结直肠癌的发生和治疗现状。然后，系统地分析了 MNPs 的多样化制备和功能化方法，接着是 MRI 相关的治疗策略。主要关注的是 CRC 管理中 MRI 介导的多模式诊断和图像引导靶向治疗的最新进展。最后，讨论了在临床实践中促进 MRI 诱导的 CRC 精确治疗学的主要挑战。
