Han Na, Yang Zhiyou, Liu Zhihui, Liu Huijing, Yin Jun
Nat Prod Commun. 2016 Aug;11(8):1181-1188.
Benzophenanthridine alkaloids belong to the benzyl isoquinoline family of alkaloids, which are mainly found in Papaveraceae and Rutaceae. To date, over.100 compounds have been isolated from natural herbal medicines which display a variety of pharmacological functions. In this paper, we have summarized the work since 1980 and our own research on benzophenanthridine alkaloids in terms of their chemical structures and distribution, biosynthesis, biotransformation and metabolism, spectral characteristics, pharmacological activities and toxicity. This review lays the foundation for further research into benzophenanthridine alkaloids and their potential applications.
苯并菲啶生物碱属于苄基异喹啉生物碱家族，主要存在于罂粟科和芸香科植物中。迄今为止，已从天然草药中分离出100多种化合物，这些化合物具有多种药理功能。在本文中，我们从苯并菲啶生物碱的化学结构与分布、生物合成、生物转化与代谢、光谱特征、药理活性和毒性等方面，总结了1980年以来的相关研究工作以及我们自己的研究成果。本综述为进一步研究苯并菲啶生物碱及其潜在应用奠定了基础。
