Lira Marcia Lanzoni Alvarenga, Almeida Mariana Abdo de, Reis-Feroldi Michele Maria, Rocha Jeanine Alvarenga
Department of Pathology, Laboratório do Vale, Taubaté (SP), Brazil.
Medical student, Universidade de Taubaté, Taubaté (SP), Brazil.
An Bras Dermatol. 2019 Jan-Feb;94(1):76-78. doi: 10.1590/abd1806-4841.20198299.
Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Cutaneous metastases from follicular carcinoma are rare and occur mainly in the head and neck area. We report a case of cutaneous metastasis in a patient with follicular thyroid carcinoma and breast carcinoma. Because of the association of these two neoplasms, the possibility of Cowden Syndrome - multiple hamartoma syndrome - was raised, but was excluded by genetic analysis of PTEN gene.
皮肤转移瘤在日常临床实践中并不常见，但却非常重要，因为它们可能是未被发现的原发性肿瘤的首发表现，或者是复发的首个迹象。女性中最常见的皮肤转移瘤来自乳腺，男性中最常见的皮肤转移瘤来自肺部。甲状腺癌尽管是最常见的内分泌肿瘤，但被认为是一种罕见肿瘤，占确诊恶性肿瘤的1%。滤泡状癌的皮肤转移瘤罕见，主要发生在头颈部区域。我们报告了一例患有滤泡状甲状腺癌和乳腺癌的患者发生皮肤转移的病例。由于这两种肿瘤的关联，引发了考登综合征（多发性错构瘤综合征）的可能性，但通过PTEN基因的基因分析将其排除。
