a Department of Endocrinology , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , India.
Gynecol Endocrinol. 2019 Jul;35(7):601-603. doi: 10.1080/09513590.2019.1566451. Epub 2019 Feb 6.
Polycystic ovary syndrome (PCOS) is a complex polygenic endocrine disorder. Familial clustering of phenotype has been known and it endorses the heritability of the disease. Among brothers of women with PCOS, we found significantly higher waist circumference, elevated blood pressure and insulin resistance when compared with age and BMI matched controls. Serum DHEAS level (6.2 vs. 4.5 μmol/L) was also significantly elevated among brothers. These findings in Indian ethnicity are concordant with previous studies and emphasize the need for counseling the first-degree family members of women with PCOS for lifestyle modification to reduce future risk of metabolic syndrome. We reiterate that insulin resistance (independent of obesity) and DHEAS may represent a PCOS phenotype. Funding agency - intramural grant Sanjay Gandhi Post Graduate Institute of Medical Sciences. CTRI registration number CTRI/2017/02/007891.
多囊卵巢综合征（PCOS）是一种复杂的多基因内分泌紊乱疾病。已知其表型具有家族聚集性，这支持了该疾病的遗传性。在患有 PCOS 的女性的兄弟中，与年龄和 BMI 匹配的对照组相比，我们发现他们的腰围更大、血压升高和胰岛素抵抗更为明显。血清 DHEAS 水平（6.2 对 4.5μmol/L）也明显升高。这些在印度裔人群中的发现与之前的研究一致，强调需要对患有 PCOS 的女性的一级家庭成员进行生活方式改变的咨询，以降低未来代谢综合征的风险。我们再次强调，胰岛素抵抗（独立于肥胖）和 DHEAS 可能代表 PCOS 的一种表型。资助机构-内部拨款圣雄甘地 PGIMS 研究所。CTRI 注册号 CTRI/2017/02/007891。
