The Francis Crick Institute, 1 Midland Road, London NW1 1ST, UK
Development. 2019 Feb 6;146(3):dev175778. doi: 10.1242/dev.175778.
Towards the end of November 2018, news broke that the Chinese researcher He Jiankui had created the world's first genome-edited babies. This came shortly before the start of the Second International Summit on Human Genome Editing, where researchers, ethicists and others concerned with regulation, social issues and public engagement from around the world gathered to discuss the latest advances in the field. In this Spotlight, I provide my perspective on the events that occurred shortly prior to and at the summit, where He Jiankui gave an account of his activities. I also discuss what was wrong with his approach and how, after more research and with appropriate regulation, clinical applications of germline genome editing in humans may be justifiable.
2018 年 11 月底，有消息称中国研究员贺建奎创造了世界上首例经过基因编辑的婴儿。这一消息是在第二届人类基因组编辑国际峰会召开前不久传出的，来自世界各地的研究人员、伦理学家和其他关注监管、社会问题和公众参与的人士齐聚一堂，讨论该领域的最新进展。在这篇特写文章中，我提供了我对峰会召开前后发生的事件的看法，贺建奎在峰会上讲述了他的活动。我还讨论了他的方法有哪些问题，以及经过更多的研究和适当的监管，人类种系基因组编辑的临床应用如何才是合理的。
