壳聚糖-植物化学物共轭物对耐抗生素鱼类致病细菌的体外抗菌及协同作用
In Vitro Antibacterial and Synergistic Effect of Chitosan-Phytochemical Conjugates Against Antibiotic Resistant Fish Pathogenic Bacteria.
作者信息
Charway Grace N A, Park Seulki, Yu Daeung, Je Jae-Young, Kim Do-Hung, Jung Won-Kyo, Kim Young-Mog
机构信息
1KOICA-PKNU International Graduate Program of Fisheries Science, Pukyong National University, Busan, 48513 Korea.
2Department of Food Science and Technology, Pukyong National University, Busan, 48513 Korea.
出版信息
Indian J Microbiol. 2019 Mar;59(1):116-120. doi: 10.1007/s12088-018-0750-0. Epub 2018 Jun 18.
Chitosan-phytochemical conjugates exhibited significant antibacterial effect with minimum inhibitory concentration (MIC) ranging from 128 to 2048 µg/ml against antibiotic-resistant fish pathogenic bacteria such as , and which were isolated from Korean cultured fish. Furthermore, the MIC values of old-fashioned antibiotics such as erythromycin and oxytertacycline drastically reduced in combination with chitosan-phytochemical conjugates against the fish pathogenic bacteria. The combination of conjugates with erythromycin and oxytetracycline gave median ∑FIC results ranging from 0.281 to 0.625 and 0.312 to 0.625, respectively. This result indicates the synergistic antibacterial effects and an increased susceptibility against the antibiotics.
壳聚糖-植物化学共轭物对从韩国养殖鱼类中分离出的抗生素抗性鱼类病原菌，如[具体细菌名称未给出]、[具体细菌名称未给出]和[具体细菌名称未给出]，表现出显著的抗菌效果，其最低抑菌浓度（MIC）范围为128至2048微克/毫升。此外，红霉素和土霉素等传统抗生素与壳聚糖-植物化学共轭物联合使用时，对鱼类病原菌的MIC值大幅降低。共轭物与红霉素和土霉素的联合使用分别产生了0.281至0.625和0.312至0.625的中位∑FIC结果。这一结果表明了协同抗菌作用以及对这些抗生素敏感性的增加。
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