群体淬灭酶的多样性：一种限制群体感应细菌群体的潜在机制。
Multiplicity of Quorum Quenching Enzymes: A Potential Mechanism to Limit Quorum Sensing Bacterial Population.
作者信息
Koul Shikha, Kalia Vipin Chandra
机构信息
Microbial Biotechnology and Genomics, CSIR - Institute of Genomics and Integrative Biology (IGIB), Delhi University Campus, Mall Road, Delhi, 110007 India.
Academy of Scientific and Innovative Research (AcSIR), 2, Rafi Marg, Anusandhan Bhawan, New Delhi, 110001 India.
出版信息
Indian J Microbiol. 2017 Mar;57(1):100-108. doi: 10.1007/s12088-016-0633-1. Epub 2016 Nov 23.
Abstract
Bacteria express certain of their characteristics especially, pathogenicity factors at high cell densities. The process is termed as quorum sensing (QS). QS operates via signal molecules such as acylhomoserine lactones (AHLs). Other bacteria inhibit QS through the inactivation of AHL signals by producing enzymes like AHL-lactonases and -acylases. Comparative genomic analysis has revealed the multiplicity of genes for AHL lactonases (up to 12 copies per genome) among spp. and that of AHL-acylases (up to 5 copies per genome) among spp. This genetic evolution can be envisaged to enable host to withstand the attacks from bacterial population, which regulates its functioning through QS.
摘要
细菌在高细胞密度时会表达其某些特性，尤其是致病因子。这个过程被称为群体感应（QS）。群体感应通过信号分子如酰基高丝氨酸内酯（AHLs）来运作。其他细菌通过产生如AHL-内酯酶和 -酰基酶等酶来使AHL信号失活，从而抑制群体感应。比较基因组分析揭示了在某些物种中AHL内酯酶基因的多样性（每个基因组多达12个拷贝）以及在某些物种中AHL-酰基酶基因的多样性（每个基因组多达5个拷贝）。可以设想这种基因进化能使宿主抵御细菌群体的攻击，细菌群体通过群体感应来调节其功能。
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