Adeosun Peter Olalekan, Fatusi Olawunmi Adedoyin, Adedeji Tewogbade Adeoye
1Oral and Maxillofacial Surgery, Obafemi Awolowo University Teaching Hospital, P. O. Box 2008, OAU Post Office, Ile-Ife, Nigeria.
2Oral and Maxillofacial Surgery, Faculty of Dentistry, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
J Maxillofac Oral Surg. 2019 Mar;18(1):106-111. doi: 10.1007/s12663-018-1105-4. Epub 2018 Mar 26.
To assess Serum Prealbumin in the severity of illness and monitor response to treatment in odontogenic space infection.
This was a prospective cohort study comprising patients being managed for odontogenic space infection at the Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria. The calculated sample size was 69. Clinical parameters (Swelling Size, Visual Analogue Scale for pain intensity, and Maximal Interincisal Distance) were measured on day 0, day 4, and day 8. Other clinical parameters were Number of Anatomic Spaces Involved, setting of treatment, and Length of Hospital Stay. Serum Prealbumin levels were also serially measured. The relationship between Serum Prealbumin level and the clinical parameters was established using Spearman's correlation test, independent test, Friedman's test, and linear regression. Significance level was set at .05.
The mean Serum Prealbumin level at presentation (day 0) was 19.19 ± 4.61 mg/dl, which was significantly lower among inpatients ( = 0.001). On days 0, 4, and 8, Serum Prealbumin negatively correlated with Number of Anatomic Spaces Involved (< 0.001). Serum Prealbumin levels on days 0, 4, and 8 and response in Serum Prealbumin negatively correlated with Length of Hospital Stay. On each day, Serum Prealbumin negatively correlated with pain intensity and Swelling Size and positively correlated with mouth opening. The response in Serum Prealbumin also positively correlated with response in each of the three clinical parameters.
This study suggests that Serum Prealbumin is a reliable tool for grading severity of illness and monitoring response to treatment in odontogenic space infection.
评估血清前白蛋白在牙源性间隙感染疾病严重程度中的作用，并监测其对治疗的反应。
这是一项前瞻性队列研究，研究对象为尼日利亚伊费奥巴费米·阿沃洛沃大学教学医院接受牙源性间隙感染治疗的患者。计算得出的样本量为69例。在第0天、第4天和第8天测量临床参数（肿胀大小、疼痛强度视觉模拟量表以及最大切牙间距离）。其他临床参数包括受累解剖间隙数量、治疗地点以及住院时间。还连续测量血清前白蛋白水平。使用Spearman相关性检验、独立样本检验、Friedman检验和线性回归确定血清前白蛋白水平与临床参数之间的关系。显著性水平设定为0.05。
就诊时（第0天）血清前白蛋白平均水平为19.19±4.61mg/dl，住院患者中该水平显著更低（P = 0.001）。在第0天、第4天和第8天，血清前白蛋白与受累解剖间隙数量呈负相关（P<0.001）。第0天、第4天和第8天的血清前白蛋白水平以及血清前白蛋白的变化与住院时间呈负相关。在每一天，血清前白蛋白与疼痛强度和肿胀大小呈负相关，与开口度呈正相关。血清前白蛋白的变化也与三个临床参数中的每一个参数的变化呈正相关。
本研究表明，血清前白蛋白是评估牙源性间隙感染疾病严重程度及监测治疗反应的可靠工具。
