Zheng Lingyan, Yang Chi, Zhang Weijie, Cai Xieyi, Kim Eric, Jiang Bin, Wang Baoli, Pu Yiping, Wang Jin, Zhang Zhiyuan, Zhou Longnv, Zhou Jian, Guan Xin
Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
J Oral Maxillofac Surg. 2012 Jul;70(7):1565-72. doi: 10.1016/j.joms.2011.07.010. Epub 2011 Oct 19.
This study aims to identify the impact of diabetes on the final outcome (length of hospital stay and development of complications) in patients with severe multispace infections in the head and neck. Furthermore, it intends to characterize significant clinical features of these patients compared with nondiabetics.
A retrospective study was conducted in 117 patients who received treatment for multispace infections of the head and neck region from 2007 through 2010 at the Department of Oral and Maxillofacial Surgery, Shanghai Ninth Hospital. The study identified diabetic patients and compared them with nondiabetic patients. Demographics, etiology of infection, clinical parameters (time from first onset of symptoms to hospital admission, number of spaces affected, and distribution of involved spaces), and laboratory values (bacteriology, admission blood glucose level, admission white blood cell count, and percentage of neutrophils on admission) were analyzed for clinical significance. Statistical analyses of the results between groups were performed using the Student t test, χ(2) test, variance analysis, logistic regression analysis, and linear regression analysis.
Admission blood glucose level was the only factor influencing the complications in multispace infections in the oral-maxillofacial region. Compared with nondiabetic patients, diabetics had infections that involved more spaces, longer hospital stays, and more frequent complications. Some diabetic patients died. The disease status (with or without diabetes) was associated with clinical outcomes (length of hospital stay and complications) in the therapy procedures.
This study identifies uncontrolled diabetes mellitus as an important indicator of clinical features and outcomes in treating multispace infections of the oral-maxillofacial region.
本研究旨在确定糖尿病对头颈部严重多间隙感染患者最终结局（住院时间和并发症发生情况）的影响。此外，本研究还旨在描述这些患者与非糖尿病患者相比的显著临床特征。
对2007年至2010年期间在上海第九人民医院口腔颌面外科接受头颈部多间隙感染治疗的117例患者进行回顾性研究。本研究确定了糖尿病患者，并将他们与非糖尿病患者进行比较。分析了人口统计学、感染病因、临床参数（从症状首次出现到入院的时间、受影响的间隙数量以及受累间隙的分布）和实验室值（细菌学、入院血糖水平、入院白细胞计数以及入院时中性粒细胞百分比）的临床意义。使用学生t检验、χ²检验、方差分析、逻辑回归分析和线性回归分析对两组结果进行统计学分析。
入院血糖水平是影响口腔颌面部多间隙感染并发症的唯一因素。与非糖尿病患者相比，糖尿病患者的感染累及更多间隙、住院时间更长且并发症更频繁。一些糖尿病患者死亡。在治疗过程中，疾病状态（有或无糖尿病）与临床结局（住院时间和并发症）相关。
本研究确定未控制的糖尿病是口腔颌面部多间隙感染治疗中临床特征和结局的重要指标。
