Tai Wanbo, Voronin Denis, Chen Jiawei, Bao Weili, Kessler Debra A, Shaz Beth, Jiang Shibo, Yazdanbakhsh Karina, Du Lanying
Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States.
Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai, China.
Front Microbiol. 2019 Jan 23;10:29. doi: 10.3389/fmicb.2019.00029. eCollection 2019.
Zika virus (ZIKV) infection during pregnancy can cause significant problems, particularly congenital Zika syndrome. Nevertheless, the potential deleterious consequences and associated mechanisms of transfusion-transmitted ZIKV infection on pregnant individuals and their fetuses and babies have not been investigated. Here we examined transmissibility of ZIKV through blood transfusion in ZIKV-susceptible pregnant A129 mice. Our data showed that transfused-transmitted ZIKV at the early infection stage led to significant viremia and broad tissue tropism in the pregnant recipient mice, which were not seen in those transfused with ZIKV-positive (ZIKV) plasma at later infection stages. Importantly, pregnant mice transfused with early-stage, but not later stages, ZIKV plasma also exhibited severe placental infection with vascular damage and apoptosis, fetal infection and fetal damage, accompanied by fetal and pup death. Overall, this study suggests that transfusion-related transmission of ZIKV during initial stage of infection, which harbors high plasma viral titers, can cause serious adverse complications in the pregnant recipients and their fetuses and babies.
孕期感染寨卡病毒（ZIKV）会引发严重问题，尤其是先天性寨卡综合征。然而，输血传播的ZIKV感染对孕妇及其胎儿和婴儿的潜在有害后果及相关机制尚未得到研究。在此，我们检测了ZIKV在对ZIKV易感的怀孕A129小鼠中通过输血的传播情况。我们的数据显示，在感染早期通过输血传播的ZIKV在怀孕的受体小鼠中导致了显著的病毒血症和广泛的组织嗜性，而在感染后期输注ZIKV阳性（ZIKV）血浆的小鼠中未观察到这种情况。重要的是，输注早期而非晚期ZIKV血浆的怀孕小鼠也表现出严重的胎盘感染，伴有血管损伤和细胞凋亡、胎儿感染和胎儿损伤，并伴有胎儿和幼崽死亡。总体而言，本研究表明，在感染初期（此时血浆病毒滴度较高）与输血相关的ZIKV传播可在怀孕受体及其胎儿和婴儿中引起严重的不良并发症。
