Department of Neurology, Gaston Bourret Territorial Hospital, Noumea, New Caledonia.
Department of Neurophysiology, Centre Hospitalier Universitaire, Toulouse, France.
J Neurovirol. 2018 Jun;24(3):362-368. doi: 10.1007/s13365-018-0621-9. Epub 2018 Mar 28.
Zika virus (ZIKV) infection has been associated with neurologic disorders including Guillain-Barré syndrome (GBS). In New Caledonia during the ZIKV outbreak (2014-2015), case-control and retrospective studies have been performed to assess the link between ZIKV and GBS. Among the 15 cases included, 33% had evidence of a recent ZIKV infection compared to only 3.3% in the 30 controls involved. All patients were Melanesian, had facial diplegia and similar neurophysiological pattern consistent with acute inflammatory demyelinating polyneuropathy, and recovered well. Furthermore, during the peak of ZIKV transmission, we observed a number of GBS cases higher than the calculated upper limit, emphasizing the fact that ZIKV is now a major trigger of GBS.
Zika 病毒（ZIKV）感染与包括格林-巴利综合征（GBS）在内的神经系统疾病有关。在新喀里多尼亚的 ZIKV 爆发期间（2014-2015 年），进行了病例对照和回顾性研究，以评估 ZIKV 与 GBS 之间的联系。在纳入的 15 例病例中，33%有近期 ZIKV 感染的证据，而 30 例对照中只有 3.3%。所有患者均为美拉尼西亚人，有面瘫，神经生理学模式相似，符合急性炎症性脱髓鞘性多发性神经病，且恢复良好。此外，在 ZIKV 传播高峰期，我们观察到的 GBS 病例数高于计算出的上限，这强调了 ZIKV 现在是 GBS 的一个主要触发因素。
