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拇趾下糖尿病足溃疡的预测因素。

Predictors of Diabetic Foot Reulceration beneath the Hallux.

机构信息

Diabetic Foot Unit, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

出版信息

J Diabetes Res. 2019 Jan 8;2019:9038171. doi: 10.1155/2019/9038171. eCollection 2019.

Abstract

AIMS

To evaluate the factors that predict reulceration beneath the hallux in people with a history of diabetic foot ulceration.

METHODS

A prospective study conducted between January 2012 and December 2014 was performed in a diabetic foot unit to assess the risk factors associated with hallux reulceration. Sixty patients with diabetic neuropathy and a history of previous ulcer were consecutively included. Sociodemographic factors and comorbidities plus the biomechanical and radiographic factors were obtained. Follow-up on participants was conducted every month, and they wore offloading therapeutic footwear and custom-made insoles. Hallux reulceration during the follow-up period was assessed as the main outcome measure in the study.

RESULTS

Patients were followed up during 29 (14.2-64.4) months. Twenty-nine patients (52%) developed a new ulceration: 9 patients (31%) in the hallux and 20 (69%) in other locations. Functional hallux limitus ( = 0.005, 95% CI (2.097-73.128), HR 12.384) and increased body mass index ( = 0.044, 95% CI (1.003-1.272), HR 1.129) were associated with the hallux ulceration-free survival time in the multivariate Cox model.

CONCLUSIONS

Obesity and the presence of functional hallux limitus increase the probability of developing hallux reulceration in patients with diabetic neuropathy and a history of ulcers.

摘要

目的

评估预测有糖尿病足溃疡病史的患者大脚趾再次发生溃疡的相关因素。

方法

本前瞻性研究于 2012 年 1 月至 2014 年 12 月在糖尿病足科进行,旨在评估与大脚趾再次溃疡相关的危险因素。连续纳入 60 例患有糖尿病神经病变且有既往溃疡史的患者。获取患者的社会人口学因素和合并症以及生物力学和影像学因素。对参与者进行每月一次的随访,他们穿着减压治疗性鞋具和定制鞋垫。将研究期间大脚趾再次溃疡作为主要观察指标。

结果

患者的随访时间为 29(14.2-64.4)个月。29 例患者(52%)发生新的溃疡:9 例(31%)在大脚趾,20 例(69%)在其他部位。大脚趾功能受限( = 0.005,95%CI(2.097-73.128),HR 12.384)和体重指数增加( = 0.044,95%CI(1.003-1.272),HR 1.129)与多因素 Cox 模型中大脚趾溃疡无复发生存时间相关。

结论

肥胖和大脚趾功能受限的存在增加了糖尿病神经病变和溃疡病史患者大脚趾再次发生溃疡的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcbf/6341251/7335319155eb/JDR2019-9038171.001.jpg

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