Department of Periodontology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Department of Prosthodontics, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Crit Rev Microbiol. 2019 Sep-Nov;45(5-6):514-538. doi: 10.1080/1040841X.2018.1553847. Epub 2019 Feb 7.
Periodontitis is a potential source of permanent systemic inflammation that initiates renal dysfunction and contributes to the development of chronic kidney diseases (CKDs). Although numerous studies have confirmed the bidirectional role of periodontal infection and renal inflammation, no literature has yet highlighted the sophisticated pathogenic mechanisms by which periodontal pathogens, particularly , induce renal dysfunction and contributed in the development of CKDs. The present review aims to critically analyze and highlight the novel pathogenesis of periodontitis induced CKDs.
牙周炎是一种潜在的全身性炎症源，它会引发肾功能障碍，并促使慢性肾脏病（CKD）的发生和发展。尽管大量研究已经证实了牙周感染和肾脏炎症之间的双向作用，但目前尚无文献强调牙周病原体（尤其是 ）诱导肾功能障碍并促使 CKD 发生和发展的复杂发病机制。本综述旨在对牙周炎引起的 CKD 的新发病机制进行批判性分析和强调。
