Department of Periodontology, University of Bern, Bern, Switzerland.
Post-Doctoral Periodontology Program, Laboratory for Immunoregulation and Tissue Engineering (LITE), Division of Periodontology, Diagnostic Sciences & Dental Hygiene, University of Southern California, Ostrow School of Dentistry, Los Angeles, CA, USA.
J Periodontol. 2019 Aug;90(8):817-820. doi: 10.1002/JPER.18-0553. Epub 2019 Mar 1.
Platelet-rich fibrin (PRF), a second-generation platelet concentrate, has been the focus of intensive research endeavors over the past 2 decades. Over the years, however, numerous reports have inaccurately reported relative centrifugal force (RCF) values, which has caused considerable confusion in the field. Furthermore, the use of trade names such as leukocyte and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) has further confused many readers, since studies have not always used centrifugation parameters with equal rotor sizes, angulation of tubes, and/or tube design. This has led to considerable misperception in the report of relative centrifugal force. Herein is described necessary parameters pivotal for the future report of RCF in studies related to PRF, which include: 1) dimensions of the rotor (radius at the clot and end of the tube); 2) rotor angulation for the tube holder; 3) revolutions per minute (RPM) and time; 4) RCF value calculated at either the RCF-minimum, RCF-clot, or RCF-maximum; 5) composition and size of tubes used to produce PRF; and 6) centrifugation model used. This editorial aims to minimize confusion in the field and create more transparent research reporting RCF values in future studies.
富血小板纤维蛋白（PRF）是第二代血小板浓缩物，在过去的 20 年中一直是密集研究的焦点。然而，多年来，许多报告不准确地报告了相对离心力（RCF）值，这在该领域造成了相当大的混乱。此外，使用商品名，如白细胞和血小板富纤维蛋白（L-PRF）和先进的血小板富纤维蛋白（A-PRF），进一步混淆了许多读者，因为研究并不总是使用具有相同转子大小、管倾斜角度和/或管设计的离心参数。这导致在报告相对离心力时产生了相当大的误解。本文介绍了与 PRF 相关的研究中报告 RCF 所需的必要参数，包括：1）转子的尺寸（凝块和管末端的半径）；2）管架的转子倾斜角度；3）每分钟转数（RPM）和时间；4）在 RCF-最小值、RCF-凝块或 RCF-最大值处计算的 RCF 值；5）用于生产 PRF 的管的组成和尺寸；和 6）使用的离心模型。本社论旨在减少该领域的混淆，并在未来的研究中创建更透明的 RCF 值研究报告。
