Leicester School of Pharmacy , De Montfort University , The Gateway, Leicester LE1 9BH , U.K.
ACS Appl Mater Interfaces. 2019 Feb 27;11(8):7823-7835. doi: 10.1021/acsami.8b22112. Epub 2019 Feb 19.
Yolk-shell particles (YSPs) have attracted increasing attention from various research fields because of their low density, large surface area, and excellent loading capacity. However, the fabrication of polymer-based porous YSPs remains a great challenge. In this work, multifunctional polycaprolactone YSPs were produced using trineedle coaxial electrospraying with a simple nonsolvent process. TiO-Ag nanoparticles and Ganoderma lucidum polysaccharides (GLPs) were encapsulated into the outer shell of the YSPs as the major antibacterial and antioxidant components, whereas iron oxide (FeO) nanoparticles were incorporated into the inner core to act as a photothermal agent. The morphology and structure, chemical composition, biocompatibility, antioxidant, and antibacterial effects of the fabricated YSPs, photothermal effects, and the release profile of the encapsulated GLP were studied in vitro. Furthermore, the in vivo wound healing effects of the YSPs and the laser-assisted therapy were explored based on a burn wound model on c57 mice.
蛋黄壳颗粒 (YSPs) 因其低密度、大比表面积和优异的负载能力而受到各个研究领域的关注。然而，基于聚合物的多孔 YSPs 的制备仍然是一个巨大的挑战。在这项工作中，使用三叉同轴电喷和简单的非溶剂工艺制备了多功能聚己内酯 YSPs。TiO-Ag 纳米粒子和灵芝多糖 (GLP) 被包裹在 YSPs 的外壳中，作为主要的抗菌和抗氧化成分，而氧化铁 (FeO) 纳米粒子则被掺入内芯作为光热剂。体外研究了制备的 YSPs 的形态和结构、化学成分、生物相容性、抗氧化和抗菌效果、光热效应以及封装 GLP 的释放情况。此外，基于 c57 小鼠的烧伤模型，研究了 YSPs 的体内愈合效果和激光辅助治疗效果。
