Department of Hand Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an Honghui Hospital North District, Xi'an, Shaanxi, 710000, People's Republic of China.
Int J Nanomedicine. 2024 Nov 3;19:11213-11233. doi: 10.2147/IJN.S490027. eCollection 2024.
Burn wounds pose intricate clinical challenges due to their severity and high risk of complications, demanding advanced therapeutic strategies beyond conventional treatments. This review discusses the application of nanoparticle-based therapies for optimizing burn wound healing. We explore the critical phases of burn wound healing, including inflammation, proliferation, and remodeling, while summarizing key nanoparticle-based strategies that influence these processes to optimize healing. Various nanoparticles, such as metal-based, polymer-based, and extracellular vesicles, are evaluated for their distinctive properties and mechanisms of action, including antimicrobial, anti-inflammatory, and regenerative effects. Future directions are highlighted, focusing on personalized therapies and the integration of sophisticated drug delivery systems, emphasizing the transformative potential of nanoparticles in enhancing burn wound treatment.
烧伤创面因其严重性和高并发症风险而带来复杂的临床挑战，需要超越传统治疗的先进治疗策略。本综述讨论了基于纳米粒子的疗法在优化烧伤创面愈合中的应用。我们探讨了烧伤创面愈合的关键阶段，包括炎症、增殖和重塑，同时总结了影响这些过程以优化愈合的关键基于纳米粒子的策略。评估了各种纳米粒子，如基于金属、基于聚合物和细胞外囊泡，以了解其独特的性质和作用机制，包括抗菌、抗炎和再生作用。强调了个性化治疗和复杂药物输送系统的整合，突出了纳米粒子在增强烧伤创面治疗方面的变革潜力。
