Department of Chemistry , Keio University , 3-14-1, Hiyoshi , Kohoku-ku, Yokohama , Kanagawa 223-8522 , Japan.
Department of Chemistry, Biology and Marine Science, Faculty of Science , University of the Ryukyus , 1 Senbaru , Nishihara , Okinawa 903-0213 , Japan.
Org Lett. 2019 Feb 15;21(4):1187-1190. doi: 10.1021/acs.orglett.9b00135. Epub 2019 Feb 7.
Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC value of 0.17 μM and rapidly induced cell death at a concentration of 2 μM. Minnamide A induced the copper-mediated accumulation of reactive oxygen species.
米那酰胺 A 是一种脂肽，具有独特的重复结构，由羟基和提议的 β-支链甲基组成。米那酰胺 A 的绝对构型通过化学降解、手性 HPLC 分析和合成方法的组合确定。米那酰胺 A 对 HeLa 细胞表现出抑制生长活性，IC 值为 0.17 μM，在 2 μM 浓度下迅速诱导细胞死亡。米那酰胺 A 诱导铜介导的活性氧的积累。
