Department of Chemistry, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi, Kohoku-ku , Yokohama , Kanagawa 223-8522 , Japan.
Department of Biosciences and Informatics, Faculty of Science and Technology , Keio University , 3-14-1 Hiyoshi, Kohoku-ku , Yokohama , Kanagawa 223-8522 , Japan.
J Nat Prod. 2018 Nov 26;81(11):2545-2552. doi: 10.1021/acs.jnatprod.8b00643. Epub 2018 Nov 2.
Hoshinoamides A (1) and B (2), new acyclic lipopeptides, were isolated from the marine cyanobacterium Caldora penicillata. Their structures were elucidated by spectroscopic analyses and degradation reactions. Hoshinoamides A (1) and B (2) did not exhibit any cytotoxicity against HeLa cells at 10 μM, but inhibited the in vitro growth of the malarial parasite Plasmodium falciparum (IC = 0.52 and 1.0 μM, respectively).
从海洋蓝藻 Caldora penicillata 中分离得到了两种新型的非环脂肽化合物 hoshinoamides A（1）和 B（2）。通过光谱分析和降解反应阐明了它们的结构。在 10 μM 时，hoshinoamides A（1）和 B（2）对 HeLa 细胞没有表现出任何细胞毒性，但抑制了疟原虫 Plasmodium falciparum 的体外生长（IC 分别为 0.52 和 1.0 μM）。
