非侵入性检测在预测妊娠慢性肝病患者结局中的应用：是否已经成熟？
Noninvasive Tests for Prognosticating Outcomes in Patients With Chronic Liver Disease in Pregnancy: Ready for Prime Time?
机构信息
Icahn School of Medicine at Mount Sinai, New York, New York, USA.
University of California, San Francisco, San Francisco, California, USA.
出版信息
Am J Gastroenterol. 2019 Feb;114(2):209-211. doi: 10.14309/ajg.0000000000000101.
Abstract
Rates of cirrhosis and pregnancy in women of reproductive age are increasing, making pregnancy-specific prognostic markers of disease severity increasingly important. Gonsalkorala et al. describe albumin-bilirubin score and aspartate aminotransferase-to-platelet ratio index as superior prognostic tools to the Model for End-Stage Liver Disease (MELD) score in predicting live births and gestation beyond 37 weeks in pregnant women with cirrhosis, among 165 pregnancies in women with chronic liver disease. However, further efforts are needed to identify diagnostic and prognostic tools during pregnancy, as well as to refine and implement a multidisciplinary team-centered approach to the care of women with chronic liver disease during pregnancy.
摘要
生育年龄女性的肝硬化和妊娠率正在上升，这使得针对疾病严重程度的特定妊娠预后标志物变得越来越重要。Gonsalkorala 等人在 165 例慢性肝病女性的 165 例妊娠中描述了白蛋白-胆红素评分和天冬氨酸氨基转移酶-血小板比值指数，它们是预测肝硬化孕妇活产和妊娠超过 37 周的更好的预后工具，优于终末期肝病模型评分（MELD 评分）。然而，仍需要进一步努力来确定妊娠期间的诊断和预后工具，并完善和实施多学科团队为中心的方法来照顾妊娠期间患有慢性肝病的女性。
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