Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 682022, India.
Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 682022, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Apr 15;213:410-415. doi: 10.1016/j.saa.2019.01.068. Epub 2019 Jan 22.
The present paper reports l-cysteine functionalized CdS quantum dots (QDs) as a simple and highly selective turn-off fluorescence sensor for the determination of tetracycline (TET). The unauthorized use of TET may pose serious health hazards in human beings and hence the detection and determination has become very essential. In this regard, we have developed a sensor that enable the quantification of TET in the range 6.00 × 10 M to 1.50 × 10 M with a limit of detection 7.78 × 10 M, under optimized conditions. Steady state and time resolved fluorescence spectroscopic studies were used for investigating the mechanism of quenching and was found to be a combination of static and dynamic processes. The analytical application of the proposed sensor was investigated in pharmaceutical formulation.
本论文报道了 L-半胱氨酸功能化的 CdS 量子点（QDs）作为一种简单且高选择性的关闭荧光传感器，用于测定四环素（TET）。TET 的未经授权使用可能会对人类健康造成严重危害，因此检测和测定变得非常必要。在这方面，我们开发了一种传感器，可以在优化条件下，在 6.00×10-6 M 至 1.50×10-6 M 的范围内定量测定 TET，检测限为 7.78×10-6 M。使用稳态和时间分辨荧光光谱研究来研究猝灭的机制，发现这是静态和动态过程的组合。所提出的传感器的分析应用在药物制剂中进行了研究。
