Wu Changhua, Guo Lei, Wang Liang, Li Jing, Wang Changfeng, Song Dan
Department of Vascular anomalies and Interventional Radiology, Qilu Children's Hospital of Shandong University, Jingshi Road, Jinan City, Shandong Province, China.
Medicine (Baltimore). 2019 Feb;98(6):e14346. doi: 10.1097/MD.0000000000014346.
Propranolol is the mainstay of treatment for infantile hemangiomas (IHs) benefited from its low complication in the present study. However, it has an uncertainty treating period with cumbersome methods which may be related to clinical features. This study sought to considered possible influences of short-term efficacy to medication.Retrospective analysis of 82 patients with IHs treated by propranolol was performed. The patients were grouped according to effect (excellent, good and fair/poor). ANOVA or t test was used to assess the relationships between effect and clinical features of IHs.Twenty-seven patients were males and 55 were females. The median age of treatment initiation was 3.5 (±2.11) months. Mean follow-up time for the group was 6.2 months (1.5-16 months). There were no significant associations between short-term efficacy and gender, time points of treatment, diameter of tumor and multifocality. However, tumor thickness was associated with short-term efficacy (P = .013). Moreover, an obvious difference of short-term efficacy has been found when tumor thickness <1.2 cm.In the present study, tumor thickness was associated with the short-term efficacy in patients with IHs. Propranolol may be gets a better outcome when tumor thickness <1.2 cm at a short time.
在本研究中，普萘洛尔是治疗婴儿血管瘤（IHs）的主要药物，因其并发症发生率低而受益。然而，它的治疗周期不确定，方法繁琐，这可能与临床特征有关。本研究旨在探讨短期疗效对用药的可能影响。对82例接受普萘洛尔治疗的IHs患者进行回顾性分析。根据疗效（优、良、中/差）对患者进行分组。采用方差分析或t检验评估疗效与IHs临床特征之间的关系。男性患者27例，女性患者55例。开始治疗的中位年龄为3.5（±2.11）个月。该组的平均随访时间为6.2个月（1.5 - 16个月）。短期疗效与性别、治疗时间点、肿瘤直径和多灶性之间无显著关联。然而，肿瘤厚度与短期疗效相关（P = 0.013）。此外，当肿瘤厚度<1.2 cm时，短期疗效存在明显差异。在本研究中，肿瘤厚度与IHs患者的短期疗效相关。当肿瘤厚度<1.2 cm时，普萘洛尔可能在短期内获得更好的疗效。
