MiR-146a基因中rs2910164多态性与银屑病易感性的关联：一项荟萃分析。
Association of rs2910164 polymorphism in MiR-146a gene with psoriasis susceptibility: A meta-analysis.
作者信息
Gong Hai-Bo, Zhang Shi-Lei, Wu Xiu-Juan, Pu Xiong-Ming, Kang Xiao-Jing
机构信息
Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang.
School of Public Health, Xinjiang Medical University, No. 393 Xinyi Road, Urumqi 830011, Xinjiang Uygur Autonomous Region, China.
出版信息
Medicine (Baltimore). 2019 Feb;98(6):e14401. doi: 10.1097/MD.0000000000014401.
The rs2910164 single nucleotide polymorphism (SNP) in miR-146a has been implicated in the etiology of psoriasis in different relevant studies with contradictory conclusions and limited sample size. Therefore, the aim of this study was to undertake a systematic review and meta-analysis to estimate the association between rs2910164 SNP and psoriasis. We searched the databases of PubMed, EMBASE, Web of Science, WanFang, and Chinese National Knowledge Infrastructure (CNKI) to identify relevant literatures published before July 15, 2018. Four case-control studies including 2212 cases and 2274 healthy controls from 4 different countries met the predetermined criteria. The effect size was pooled by odds ratios (ORs) and 95% confidence intervals (95%CIs). Recessive model (CC vs CG+GG) was confirmed to be the optimal model. The results indicated that rs2910164 SNP was significantly associated with psoriasis (OR = 0.74, 95%CI 0.60-0.91, P = .004), and individuals with CC-genotype were predisposed to have decreased risk of psoriasis.
在不同的相关研究中，miR-146a中的rs2910164单核苷酸多态性（SNP）与银屑病的病因有关，但结论相互矛盾且样本量有限。因此，本研究的目的是进行系统评价和荟萃分析，以评估rs2910164 SNP与银屑病之间的关联。我们检索了PubMed、EMBASE、Web of Science、万方和中国知网（CNKI）数据库，以识别2018年7月15日前发表的相关文献。四项病例对照研究（包括来自4个不同国家的2212例病例和2274例健康对照）符合预定标准。效应量通过比值比（OR）和95%置信区间（95%CI）进行合并。隐性模型（CC与CG+GG）被确认为最佳模型。结果表明，rs2910164 SNP与银屑病显著相关（OR = 0.74，95%CI 0.60 - 0.91，P = 0.004），CC基因型个体患银屑病的风险倾向于降低。
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