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[霍奇金病患者切除淋巴结中B淋巴细胞和T淋巴细胞的比例]

[Proportion of B- and T-lymphocytes in lymph nodes removed from patients with Hodgkin's disease].

作者信息

Pluzzańska A, Robak T, Szadowska A, Kabza R, Tume Z, Maciejczyk J, Mazurowa A

出版信息

Acta Haematol Pol. 1978 Jan-Mar;9(1):19-24.

PMID:307324
Abstract

The proportions of T and B lymphocytes were determined in lymph nodes removed from 30 patients with Hodgkin's disease and in 18 control lymph nodes. In all lymph nodes obtained from patients with Hodgkin's disease histological examination demonstrated presence of typical granulation tissue of type Ns, Mc, Ld (changes of Lp type were not found). In the control lymph nodes no neoplastic changes or inflammatory reactions were observed. For identification of T cells the rosette test E was used and for identification of B cells --- the EAC rosette test and tests for presence of Ig on their surface by the immunofluorescent method (L Ig+). It was found that the proportions of T and B cells in the lymph nodes obtained from patients with Hodgkin's disease were not different from those in control lymph nodes. The percent values of T and B cells were similar in all three histological types of changes in Hodgkin's disease. Early radiotherapy was not connected with a change in T and B cell proportions in the irradiated lymph nodes.

摘要

测定了30例霍奇金病患者切除的淋巴结及18个对照淋巴结中T淋巴细胞和B淋巴细胞的比例。在所有取自霍奇金病患者的淋巴结中,组织学检查显示存在典型的Ns、Mc、Ld型肉芽组织(未发现Lp型改变)。在对照淋巴结中未观察到肿瘤性改变或炎症反应。用E玫瑰花结试验鉴定T细胞,用EAC玫瑰花结试验及免疫荧光法检测其表面Ig的存在(L Ig+)来鉴定B细胞。结果发现,霍奇金病患者淋巴结中T细胞和B细胞的比例与对照淋巴结中的比例无差异。在霍奇金病的所有三种组织学改变类型中,T细胞和B细胞的百分比值相似。早期放疗与照射淋巴结中T细胞和B细胞比例的改变无关。

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