Department of Anatomy, Faculty of Basic medical Sciences, College of Medicine, Alex Ekwueme Federal University Ndufu-Alike Ikwo (AE-FUNAI), Ebonyi State, P.M.B. 1010, Nigeria.
Department of Anatomy, Faculty of Basic medical Sciences, University of Nigeria Enugu Campus (UNEC), Enugu State, Nigeria.
J Trace Elem Med Biol. 2019 Mar;52:192-198. doi: 10.1016/j.jtemb.2018.12.016. Epub 2018 Dec 31.
Lead without nutritional value is a widely studied occupational and environmental toxicant. Leads' toxic effects on female reproduction are decreased fertility, inability to sustain pregnancy and reduced pregnancy.
This study aimed at examining the effect of oral administration of lead acetate (1.5 mg/kg) on the histology of female albino Wistar rats' ovary and Uterus and the extracts' protective role against toxicity.
The experiment took 28 days involving 25 female Wistar rats divided into 5 groups A, B, C, D and E. A is an untreated group that received normal saline, D lead acetate group that received lead acetate solution, E received aqueous extract, B and C low and high dose of aqueous extract respectively and lead acetate solution.
The positive control group showed a significant increase in SOD at P ≤ 0.01 compared to the negative control. Group E showed significant decrease ovarian SOD. The organs weights were significantly reduced in group D. The changes seen in the organs include oedema, necrosis, optical empty spaces, denudations and fatty changes. Administrating the extract protected the organs against the lead acetate. These alterations are shown to cause infertility in female rats.
The results suggested that the extract has protective role against lead reproductive toxicity.
铅是一种具有广泛研究价值的职业性和环境性毒物，没有营养价值。铅对女性生殖的毒性作用表现为生育能力下降、妊娠能力丧失和妊娠减少。
本研究旨在研究醋酸铅（1.5mg/kg）口服给药对雌性白化 Wistar 大鼠卵巢和子宫组织学的影响，以及提取物对毒性的保护作用。
实验持续 28 天，涉及 25 只雌性 Wistar 大鼠，分为 5 组 A、B、C、D 和 E。A 组为未处理组，给予生理盐水；D 组为醋酸铅组，给予醋酸铅溶液；E 组给予水提取物；B 组和 C 组分别给予低剂量和高剂量的水提取物和醋酸铅溶液。
阳性对照组 SOD 显著增加，P≤0.01，与阴性对照组相比。E 组卵巢 SOD 显著降低。D 组器官重量明显减轻。观察到的器官变化包括水肿、坏死、光学空泡、剥脱和脂肪变性。给予提取物可保护器官免受醋酸铅的影响。这些改变被认为会导致雌性大鼠不孕。
结果表明，该提取物对铅的生殖毒性具有保护作用。
