Watcho Pierre, Ngadjui Esther, Alango Nkeng-Efouet P, Benoît Nguelefack T, Kamanyi Albert
Animal Physiology and Phytopharmacology Laboratory, Department of Animal Biology, Faculty of Science,University of Dschang, BOX 67 Dschang, Cameroon.
Afr Health Sci. 2009 Mar;9(1):49-53.
The reproductive effects of Ficus asperifolia in female rats were investigated in the present study. Sperm-positive adult female rats were orally administered (P.O.) either the aqueous and methanol extracts of Ficus asperifolia (100 and 500mg/kg), distilled water (10ml/kg) or 5%Tween 80 (10ml/kg) for seven days. On day 10 of pregnancy, the implantation sites were recorded. In the fertility study, adult female rats received the same test substances for 21 days and, the fertility index and litter size determined. In the uterotrophic test, normal and ovariectomized immature rats were treated for seven days with the dry extract of Ficus asperifolia (100 and 500mg/kg) in the absence and presence of 17ȃ-estradiol benzoate 1µg/animal/day, s.c. On day 8, the uterine growth index was measured. Results of the study showed a significant increase (p<0.05) in the implantation sites and litter size of animals receiving 100mg/kg of the aqueous extract of Ficus asperifolia. In the estrogenic assay, normal immature rats were sensitive to the treatment with Ficus asperifolia than the ovariectomized ones. Our results give added scientific support to the popular use of Ficus asperifolia in the treatment of some cases of women's sterility/infertility related problems.
本研究调查了粗叶榕对雌性大鼠的生殖影响。对精子呈阳性的成年雌性大鼠口服给予粗叶榕的水提取物和甲醇提取物（100和500mg/kg）、蒸馏水（10ml/kg）或5%吐温80（10ml/kg），持续7天。在妊娠第10天，记录着床部位。在生育力研究中，成年雌性大鼠接受相同的受试物质21天，然后测定生育力指数和产仔数。在子宫增重试验中，正常和去卵巢的未成熟大鼠在有无皮下注射1μg/动物/天苯甲酸雌二醇的情况下，用粗叶榕干提取物（100和500mg/kg）处理7天。在第8天，测量子宫生长指数。研究结果显示，接受100mg/kg粗叶榕水提取物的动物的着床部位和产仔数显著增加（p<0.05）。在雌激素测定中，正常未成熟大鼠比去卵巢大鼠对粗叶榕处理更敏感。我们的结果为粗叶榕在治疗某些女性不育/不孕相关问题中的广泛应用提供了更多的科学支持。
