Division of Oral and Maxillofacial Surgery, Oral Medicine and Oral Pathology, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland.
Division of Oral Biosciences, School of Dental Science, Trinity College Dublin, Dublin Dental University Hospital, Dublin, Ireland.
Oral Oncol. 2019 Feb;89:30-33. doi: 10.1016/j.oraloncology.2018.12.003. Epub 2018 Dec 17.
Recent advances in DNA sequencing technology have facilitated rapid advances in the analysis of the human microbiome and its role in human disease. Several studies have now shown that OSCC and some oral premalignant conditions are associated with alterations in the oral microbiome. These studies raise questions regarding the role of the oral microbiome in the progression of oral malignancies and whether microbiome change is a significant risk factor in the development of oral cancer. This short review summarises current knowledge in the field and highlights questions that require further investigation.
近年来，DNA 测序技术的进步促进了人类微生物组及其在人类疾病中的作用的快速分析。目前已有几项研究表明，口腔鳞状细胞癌（OSCC）和一些口腔癌前病变与口腔微生物组的改变有关。这些研究提出了一些问题，即口腔微生物组在口腔恶性肿瘤的进展中扮演了何种角色，以及微生物组的改变是否是口腔癌发生的一个重要危险因素。本文简要综述了该领域的现有知识，并强调了需要进一步研究的问题。
