Surgical Department of Oral and Maxillofacial Oncology, the First Affiliated Hospital of Xinjiang Medical University. Urumqi 830054, China.
School / Hospital of Stomatology, Xinjiang Medical University. Urumqi 830011, China.
Asian Pac J Cancer Prev. 2022 Jul 1;23(7):2199-2213. doi: 10.31557/APJCP.2022.23.7.2199.
Oral cancer, with an around 50% mortality rate, is one of the most common malignancies world-wide. It is often detected in advanced or terminal stage and has a poor prognosis, although substantial progress in cancer management. Microbiome has become an increasingly recognized factor that may contribute to the cancerous development. Oral microbiological population comprising more than 700 bacterial species, varies since saliva and different habitats of oral cavity. A shift of composition of oral microbiome from usual condition to functional inflammation to pathological state has been discovered amongst patients with premalignant disorders and oral carcinoma, with evidence suggesting the tumor microenvironment (TME) could strongly exacerbate the influence of oral microorganisms. The complex interactions taking place in either cancer formation or progression have been evaluated in several publications, however given their results' heterogeneity, a review is needed to correctly untangle the potential correlation in this group of pro-carcinogenesis. In this review, we briefly summarize our current knowledge of the role of oral microbiome, focusing on its potential crosstalk with TME in oral squamous cell carcinomas (OSCC) more precisely, and pave the way for manipulating oral microbiome to deal with OSCC in the future.
口腔癌的死亡率约为 50%，是全球最常见的恶性肿瘤之一。尽管癌症治疗取得了实质性进展，但口腔癌通常在晚期或终末期才被发现，预后较差。微生物组已成为一个日益被认可的因素，可能有助于癌症的发展。口腔微生物群由超过 700 种细菌组成，由于唾液和口腔不同栖息地的存在而有所不同。在癌前病变和口腔癌患者中，已经发现口腔微生物组的组成从正常状态到功能性炎症再到病理状态发生了变化，有证据表明肿瘤微环境（TME）可能会强烈加剧口腔微生物的影响。在这方面已经有一些出版物评估了在癌症形成或进展过程中发生的复杂相互作用，但由于其结果存在异质性，因此需要进行综述以正确理清这组促癌发生的潜在相关性。在这篇综述中，我们简要总结了我们目前对口腔微生物组作用的认识，重点关注其与口腔鳞状细胞癌（OSCC）中 TME 的潜在串扰，并为未来操纵口腔微生物组以应对 OSCC 铺平道路。
