Children's Minnesota Sleep Center, Children's Minnesota, Minneapolis, MN.
Children's Minnesota Research Institute, Children's Minnesota, Minneapolis, MN.
J Pediatr. 2019 Apr;207:192-197.e1. doi: 10.1016/j.jpeds.2018.12.026. Epub 2019 Feb 4.
To evaluate the efficacy of low dose ferrous sulfate for the treatment of iron deficiency and if the probiotic Lactobacillus plantarum 299v (LP299v) enhances treatment.
This randomized, double-blinded, controlled trial of the treatment of iron deficiency in children compared the use of low-dose ferrous sulfate (1-3 mg/kg/day), with or without probiotic (LP299v).
Serum ferritin level increased in all children from a baseline of 23.7 ng/mL to 45.4 ng/mL after 6-8 weeks of treatment. There was no significant difference in the increase in serum ferritin in children taking the probiotic LP299v compared with controls (23.2 vs 20.0 ng/mL, respectively). Additionally, an increase in ferritin level was not significantly associated with probiotic use when controlling for other factors, including child weight and dosing. Overall, the treatments were well-tolerated, with mild side effects.
Treatment with low-dose ferrous sulfate is well-tolerated and effective in correcting iron deficiency in children. However, the probiotic LP299v did not enhance treatment. Further attention should examine the dose-response effect in children, including an alternate day dosing schedule.
ClinicalTrials.gov: NCT01617044.
评估低剂量硫酸亚铁治疗缺铁症的疗效，以及益生菌植物乳杆菌 299v（LP299v）是否能增强治疗效果。
这是一项随机、双盲、对照临床试验，比较了低剂量硫酸亚铁（1-3mg/kg/天）单独使用与联合使用益生菌（LP299v）治疗儿童缺铁症的效果。
所有儿童的血清铁蛋白水平均从基线的 23.7ng/mL 增加到 6-8 周治疗后的 45.4ng/mL。服用益生菌 LP299v 的儿童与对照组相比（分别为 23.2 和 20.0ng/mL），血清铁蛋白水平的增加没有显著差异。此外，当控制儿童体重和剂量等其他因素时，铁蛋白水平的增加与益生菌的使用也没有显著相关性。总体而言，两种治疗方法均耐受良好，仅有轻微的副作用。
低剂量硫酸亚铁治疗缺铁症在儿童中耐受良好且有效。然而，益生菌 LP299v 并未增强治疗效果。进一步的研究应关注儿童中的剂量反应效应，包括隔日给药方案。
ClinicalTrials.gov：NCT01617044。
