Probi AB, 223 70 Lund, Sweden.
Biomedical Nutrition, Pure and Applied Biochemistry, Center for Applied Life Sciences, Lund University, 221 00 Lund, Sweden.
Nutrients. 2020 Apr 30;12(5):1279. doi: 10.3390/nu12051279.
Iron is an essential micronutrient for oxygen transport and mitochondrial metabolism and is critical for physical performance. Compromised iron stores are more commonly found among athletes, and females are especially at risk. Iron deficiency is generally treated using oral iron supplements. However, only a small proportion of ingested iron is absorbed, necessitating higher intakes, which may result in adverse side effects, reduced compliance, and inefficient repletion of iron stores. The probiotic strain 299v (Lp299v) significantly increases intestinal iron absorption in meal studies. The present study was conducted to explore the effects of 20 mg of iron with or without Lp299v on iron status, mood state, and physical performance. Fifty-three healthy non-anemic female athletes with low iron stores (ferritin < 30 μg/L) were randomized, and 39 completed the study. Intake of Lp299v with iron for four weeks increased ferritin levels more than iron alone (13.6 vs. 8.2 µg/L), but the difference between the groups was not significant ( = 0.056). The mean reticulocyte hemoglobin content increased after intake of Lp299v compared to control (1.5 vs. 0.82 pg) after 12 weeks, but the difference between the group was not significant ( = 0.083). The Profile of Mood States (POMS) questionnaire showed increased vigor with Lp299v vs. iron alone after 12 weeks (3.5 vs. 0.1, = 0.015). No conclusive effects on physical performance were observed. In conclusion, Lp299v, together with 20 mg of iron, could result in a more substantial and rapid improvement in iron status and improved vigor compared to 20 mg of iron alone. A larger clinical trial is needed to further explore these findings as well as the impact of Lp299v on physical performance.
铁是氧气运输和线粒体代谢所必需的微量元素，对身体表现至关重要。运动员中更常见铁储存不足，而女性的风险尤其高。缺铁通常采用口服铁补充剂治疗。然而，只有一小部分摄入的铁被吸收，需要更高的摄入量，这可能导致不良反应、降低依从性和铁储存补充效率低下。益生菌菌株 299v（Lp299v）在膳食研究中显著增加肠道铁吸收。本研究旨在探索 20 毫克铁与或不与 Lp299v 对铁状态、情绪状态和身体表现的影响。53 名铁储存量低（铁蛋白<30μg/L）的健康非贫血女性运动员被随机分组，其中 39 名完成了研究。四周内摄入 Lp299v 与铁可使铁蛋白水平升高超过单独摄入铁（13.6 与 8.2μg/L），但两组之间的差异无统计学意义（=0.056）。12 周后，与对照组相比，摄入 Lp299v 后网织红细胞血红蛋白含量增加（1.5 与 0.82pg），但两组之间的差异无统计学意义（=0.083）。12 周后，与单独摄入铁相比，Lp299v 可使状态问卷（POMS）中的活力增加（3.5 与 0.1，=0.015）。未观察到对身体表现的明确影响。总之，与单独摄入 20 毫克铁相比，Lp299v 与 20 毫克铁一起使用可能会更显著、更快地改善铁状态和提高活力。需要更大的临床试验来进一步探讨这些发现以及 Lp299v 对身体表现的影响。
