Yıldız Yasin, Topçu Atilla, Mercantepe Tolga, Arpa Medeni, Yıldız İlknur Esen, Tümkaya Levent
Department of Paediatrics, Faculty of Medicine, Recep Tayyip Erdoğan University, 53200 Rize, Türkiye.
Department of Pharmacology, Faculty of Medicine, Recep Tayyip Erdoğan University, 53200 Rize, Türkiye.
Nutrients. 2025 Mar 26;17(7):1150. doi: 10.3390/nu17071150.
There are many studies on the chemical and enzymatic interactions of probiotics, and the effects of 299v on iron absorption have been clearly shown. The aim of this study was to investigate the effect of probiotics on the absorption of iron in molasses. Wistar rats ( = 46) were taken four weeks after birth and divided into seven groups. Iron deficiency anemia was induced by giving "iron purified pellet" to the groups except the control group for four weeks and then the groups were given nutrients for eight weeks. In addition to iron deficiency anemia tests, immunohistochemical markers such as SCL11a, IRE1, Wnt2, and CD71 were examined. The mean weight of the subjects was 309.5 ± 63.9 (226-424) g and no significant difference was observed in the laboratory values of metabolic data. When the laboratory values of iron deficiency anemia were examined, a statistically significant difference was found between the mean ferritin ( = 0.03) and hepcidin ( = 0.02) values of the groups. Iron absorption analysis values were generally higher in the group receiving Fe as expected. However, when the groups receiving molasses and additives were compared, the highest plasma iron level and Hb value were found in the 299v group, and the highest ferritin and hepcidin levels were found in the Multiprobiotic group. No difference was observed between the body weights and fasting serum glucose levels of the groups despite daily molasses consumption, indicating the metabolic proactive effects of probiotics. Although no significant difference was detected between the groups receiving probiotics, iron absorption in molasses was increased with probiotic supplementation.
关于益生菌的化学和酶促相互作用有许多研究,并且299v对铁吸收的影响已得到明确证实。本研究的目的是调查益生菌对糖蜜中铁吸收的影响。出生四周后的46只Wistar大鼠被分为七组。除对照组外,其余各组给予“铁纯化颗粒”四周以诱导缺铁性贫血,然后各组给予营养物质八周。除了进行缺铁性贫血测试外,还检测了SCL11a、IRE1、Wnt2和CD71等免疫组化标志物。受试者的平均体重为309.5±63.9(226 - 424)g,代谢数据的实验室值未观察到显著差异。检查缺铁性贫血的实验室值时,各组的平均铁蛋白(P = 0.03)和铁调素(P = 0.02)值之间存在统计学显著差异。正如预期的那样,接受铁的组中铁吸收分析值通常较高。然而,比较接受糖蜜和添加剂的组时,299v组的血浆铁水平和血红蛋白值最高,多益生菌组的铁蛋白和铁调素水平最高。尽管每天食用糖蜜,但各组之间的体重和空腹血清葡萄糖水平未观察到差异,表明益生菌具有代谢促进作用。虽然接受益生菌的组之间未检测到显著差异,但补充益生菌可增加糖蜜中铁的吸收。