The MacDiarmid Institute for Advanced Materials and Technology, Department of Physics and Chemistry , The University of Auckland , Auckland 1010 , New Zealand.
ACS Appl Mater Interfaces. 2019 Mar 6;11(9):8928-8936. doi: 10.1021/acsami.8b22075. Epub 2019 Feb 20.
There is a pressing need to advance our ability to construct three-dimensional (3D) functional bioelectronic interfaces. Additionally, to ease the transition to building cellular electronic systems, a remote approach to merge electrical components with biology is desirable. By combining 3D digital inkjet printing with bipolar electrochemistry, we remotely control and fabricate conductive wires, forming a first of its kind contactless bionic manufacturing procedure. It enables controlled fabrication of conductive wires in a three-dimensional configuration. Moreover, we demonstrate that this technology could be used to grow and interface conductive conduits in situ with mammalian cells, offering a new strategy to engineering bioelectronic interfaces. This represents a step change in the production of functional complex circuitry and considerably increases the manufacturing capabilities of merging cells with electronics. This approach provides a platform to construct bioelectronics in situ offering a potential paradigm shift in the methods for building bioelectronics with potential applications in biosensing and bioelectronic medicine.
迫切需要提高我们构建三维（3D）功能生物电子接口的能力。此外，为了便于向构建细胞电子系统过渡，人们希望采用远程方法将电子元件与生物学结合。通过将 3D 数码喷墨打印与双极电化学相结合，我们远程控制和制造导电丝，形成首例非接触仿生制造工艺。它能够以三维结构控制地制造导电丝。此外，我们证明该技术可用于原位生长和与哺乳动物细胞接口的导电管道，为工程生物电子接口提供了一种新策略。这代表了功能复杂电路生产的重大转变，并极大地提高了细胞与电子融合的制造能力。这种方法为构建生物电子学提供了一个原位构建的平台，为构建生物电子学的方法提供了潜在的范式转变，在生物传感和生物电子医学中有潜在的应用。
