García-Ríos Antonio, Camargo Garcia Antonio, Perez-Jimenez Francisco, Perez-Martinez Pablo
Unidad de Lípidos y Arteriosclerosis, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Universidad de Córdoba, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Córdoba, España.
Unidad de Lípidos y Arteriosclerosis, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía, Universidad de Córdoba, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Córdoba, España.
Clin Investig Arterioscler. 2019 Jul-Aug;31(4):178-185. doi: 10.1016/j.arteri.2018.11.003. Epub 2019 Feb 6.
Cardiovascular disease remains the first cause of mortality in Western countries. New strategies for prevention and control of cardiovascular disease are needed. At the same time, the incidence of risk factors that lead to the development of this disease, such as obesity, hypertension and diabetes, continues to rise. Therefore, the search for new markers or mediators is a priority in most cardiovascular prevention programs. The study of the intestinal microbiota is emerging because it is known that intestinal microorganisms act collectively as an integrated organ, regulating multiple biological functions that can modulate cardiovascular risk factors and the pathogenic mechanisms of this process. This review considers the current situation regarding the influence of gut microbiota on cardiovascular disease and particularly, its influence on the main traditional risk factors that lead to cardiovascular disease, such as obesity, diabetes, hypertension and lipids.
心血管疾病仍然是西方国家的首要死因。需要采取新的心血管疾病预防和控制策略。与此同时，导致这种疾病发生的危险因素，如肥胖、高血压和糖尿病的发病率持续上升。因此，寻找新的标志物或介质是大多数心血管预防项目的首要任务。肠道微生物群的研究正在兴起，因为已知肠道微生物共同作为一个整合器官发挥作用，调节多种生物学功能，这些功能可以调节心血管危险因素以及该过程的致病机制。本文综述了肠道微生物群对心血管疾病影响的现状，特别是其对导致心血管疾病的主要传统危险因素，如肥胖、糖尿病、高血压和血脂的影响。
