Chemomicrobiomics Laboratory, KMCH Research Foundation, Kovai Medical Center and Hospital, Coimbatore 641 014, Tamil Nadu, India.
Chemomicrobiomics Laboratory, KMCH Research Foundation, Kovai Medical Center and Hospital, Coimbatore 641 014, Tamil Nadu, India.
Trends Endocrinol Metab. 2020 Nov;31(11):835-847. doi: 10.1016/j.tem.2020.01.013. Epub 2020 Feb 11.
Diabetes and cardiovascular disease (CVD) have evolved as the leading cause of mortality and morbidity worldwide. In addition to traditional risk factors, recent studies have established that the human microbiota, particularly gut bacteria, plays a role in the development of diabetes and CVD. Although the presence of microbes in blood has been known for centuries, mounting evidence in this metagenomic era provides new insights into the role of the blood microbiota in the pathogenesis of non-infectious diseases such as diabetes and CVD. We highlight the origin and physiology of the blood microbiota and circulating microbial metabolites in relation to the etiology and progression of diabetes and CVD. We also discuss translational perspectives targeting the blood microbiota in the diagnosis and treatment of diabetes and CVD.
糖尿病和心血管疾病（CVD）已成为全球范围内主要的致死和致残原因。除了传统的危险因素外，最近的研究还表明，人类微生物组，特别是肠道细菌，在糖尿病和 CVD 的发展中发挥作用。尽管血液中存在微生物已经有几个世纪的历史，但在这个宏基因组时代，越来越多的证据提供了新的见解，即血液微生物组在糖尿病和 CVD 等非传染性疾病的发病机制中的作用。我们强调了血液微生物组和循环微生物代谢物的起源和生理学，以及它们与糖尿病和 CVD 的病因和进展的关系。我们还讨论了针对血液微生物组在糖尿病和 CVD 的诊断和治疗中的转化观点。
