Gomez Christian R, Nomellini Vanessa, Faunce Douglas E, Kovacs Elizabeth J
The Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, IL 60153, USA.
Exp Gerontol. 2008 Aug;43(8):718-28. doi: 10.1016/j.exger.2008.05.016. Epub 2008 Jun 11.
Advanced age is associated with defects in all of the cells of the innate immune system, including numbers, function, and early stages of activation. This review, presents the current state of the field on the impact of age on the innate immune system. The analysis of the literature suggests that a dysfunctional innate immune system is a contributing factor to aberrant outcomes after injury or infection and to the development of many of the diseases observed in the elderly. Gaining an understanding of the nature of the defects in innate immune cells may allow the development of therapeutic strategies aimed to restore innate immune function in aged individuals.
高龄与先天性免疫系统所有细胞的缺陷相关,包括数量、功能及激活的早期阶段。本综述介绍了该领域关于年龄对先天性免疫系统影响的现状。文献分析表明,功能失调的先天性免疫系统是损伤或感染后异常结果以及老年人中许多疾病发生的一个促成因素。了解先天性免疫细胞缺陷的本质可能有助于制定旨在恢复老年个体先天性免疫功能的治疗策略。