Department of Radiology, Chonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Chonbuk, 54907, Korea.
Research Institute of Clinical Medicine of Chonbuk National University, Jeonju, Korea.
Abdom Radiol (NY). 2019 May;44(5):1808-1815. doi: 10.1007/s00261-019-01924-5.
To compare the apparent diffusion coefficient (ADC) value of conventional diffusion-weighted imaging (cDWI) to simultaneous multislice-accelerated DWI (sDWI) and to evaluate the possibility of ADC normalization using the spleen as a reference organ.
We retrospectively evaluated 92 patients (68 men, 24 women; mean age 60.0 years) who underwent liver magnetic resonance imaging (MRI) including both cDWI and sDWI. sDWI was obtained with an acceleration factor of 2. ADC values were measured from the right liver lobe, left liver lobe, spleen, pancreas, right kidney, and left kidney. ADC values of the spleen were used for normalization. Paired sample t test, Pearson's correlation coefficient, and Bland-Altman method were used for statistical analysis.
ADC values of cDWI were significantly lower than sDWI in all six anatomic regions (p < 0.001). The mean difference in ADC value between cDWI and sDWI ranged from 0.048 to 0.125 × 10 mm/s. ADC values from cDWI and sDWI showed a moderate to very high positive correlation (p < 0.001). After ADC normalization using the spleen as a reference organ, there was no significant difference between normalized ADC of cDWI and sDWI in all 5 anatomic regions (p = 0.11 - 0.74).
Normalization of ADC using the spleen could be useful for comparing upper abdominal organs acquired with either cDWI or sDWI in longitudinal and follow-up studies.
比较常规弥散加权成像（cDWI）与同时多层加速弥散加权成像（sDWI）的表观弥散系数（ADC）值，并评估使用脾脏作为参考器官进行 ADC 归一化的可能性。
我们回顾性评估了 92 例（68 名男性，24 名女性；平均年龄 60.0 岁）接受肝脏磁共振成像（MRI）检查的患者，包括 cDWI 和 sDWI。sDWI 的加速因子为 2。从右肝、左肝、脾脏、胰腺、右肾和左肾测量 ADC 值。使用脾脏 ADC 值进行归一化。采用配对样本 t 检验、皮尔逊相关系数和 Bland-Altman 方法进行统计学分析。
cDWI 的 ADC 值在所有六个解剖区域均显著低于 sDWI（p < 0.001）。cDWI 和 sDWI 之间 ADC 值的平均差值范围为 0.048 至 0.125×10 mm/s。cDWI 和 sDWI 的 ADC 值之间呈中度至非常高的正相关（p < 0.001）。使用脾脏作为参考器官进行 ADC 归一化后，在所有 5 个解剖区域，cDWI 和 sDWI 的归一化 ADC 值之间无统计学差异（p = 0.11 至 0.74）。
使用脾脏对 ADC 进行归一化可用于比较使用 cDWI 或 sDWI 采集的上腹部器官的纵向和随访研究。
