Chen Yukun, Yang Panpan, Fu Caixia, Bian Yun, Shao Chengwei, Ma Chao, Lu Jianping
Department of Radiology, Changhai Hospital of Shanghai, Naval Medical University, Shanghai, 200433, China.
Application Developments, Siemens Shenzhen Magnetic Resonance Ltd., Siemens Healthineers, Shenzhen, 518057, China.
Heliyon. 2023 Jul 12;9(7):e18166. doi: 10.1016/j.heliyon.2023.e18166. eCollection 2023 Jul.
Evaluation of the variabilities in apparent diffusion coefficient (ADC) measurements of the spleen (ADC) and the paraspinal muscles (ADC) to identify the reference organ for normalizing the ADC from the abdominal diffusion weighted imaging (DWI).
Two MRI scanners, with 314 abdominal exams on the GE and 929 on the Siemens system, were used for MRI examinations including DWI (b-values, 50 and 800 s/mm). For a subset of 73 exams on the Siemens system a second exam was conducted. Four regions of interest (ROIs) in each exam were placed to measure the ADC and the bilateral ADC. ADC variability between patients (on each scanner separately), ADC variability due to ROI placement between the two ROIs in each organ, and variability in the subset between the first and second exams were assessed.
The ADC was more scattered and variable than the ADC in the comparability (n = 929 and 314 for two MRI scanners, respectively) and repeatability (n = 73) datasets. The Bland-Altmann bias and limits of agreement (LoAs) for the ADC (ICC, 0.47; CV, 0.070) and ADC (ICC, 0.67; CV, 0.023) in the repeatability datasets (n = 73) were -0.1 (-25.7%-25.6%) and -0.3 (-8.8%-8.1%), respectively. For the Siemens system, the Bland-Altmann bias and LoAs for the ADC (ICC, 0.72; CV, 0.061) and ADC (ICC, 0.53; CV, 0.030) in the comparability datasets (n = 929) were 2.1 (-20.0%-24.2%) and 0.7 (-10.0%-11.4%), respectively. Similar findings have been found in the GE system (n = 314). The CVs for the ADC measurements were lower than those of the ADC both in the repeatability and the comparability analyses (all p < 0.001).
Paraspinal muscles demonstrate better reference characteristics than the spleen in estimating ADC variability of abdominal DWI.
评估脾脏表观扩散系数（ADC）测量值和椎旁肌ADC测量值的变异性，以确定用于标准化腹部扩散加权成像（DWI）中ADC的参考器官。
使用两台MRI扫描仪，GE系统上进行了314例腹部检查，西门子系统上进行了929例。MRI检查包括DWI（b值为50和800 s/mm²）。在西门子系统的73例检查子集中进行了第二次检查。每次检查中放置四个感兴趣区域（ROI）来测量ADC和双侧ADC。评估了患者之间（分别在每台扫描仪上）的ADC变异性、每个器官中两个ROI之间由于ROI放置导致的ADC变异性以及第一次和第二次检查之间子集中的变异性。
在可比性数据集（两台MRI扫描仪分别为n = 929和314）和重复性数据集（n = 73）中，脾脏ADC比椎旁肌ADC更分散且变异性更大。重复性数据集（n = 73）中脾脏ADC（组内相关系数[ICC]，0.47；变异系数[CV]，0.070）和椎旁肌ADC（ICC，0.67；CV，0.023）的Bland-Altmann偏差和一致性界限（LoA）分别为-0.1（-25.7%至25.6%）和-0.3（-8.8%至8.1%）。对于西门子系统，可比性数据集（n = 929）中脾脏ADC（ICC，0.72；CV，0.061）和椎旁肌ADC（ICC，0.53；CV，0.030）的Bland-Altmann偏差和LoA分别为2.1（-20.0%至24.2%）和0.7（-10.0%至11.4%）。GE系统（n = 314）中也发现了类似结果。在重复性和可比性分析中，脾脏ADC测量的CV均低于椎旁肌ADC的CV（所有p < 0.001）。
在估计腹部DWI的ADC变异性方面，椎旁肌比脾脏表现出更好的参考特征。
