Department of Dermatology, Tel Aviv Sourasky Medical Center, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Photodermatol Photoimmunol Photomed. 2019 Jul;35(4):214-220. doi: 10.1111/phpp.12454. Epub 2019 Feb 27.
Glutathione S-transferases (GSTs) play a critical role in cellular protection against oxidative damage. Polymorphisms in three major GST loci have been described. A number of studies have looked for an association between GSTs and skin diseases.
To ascertain the possibility that polymorphisms in the GSTM1, GSTT1, and GSTP1 genes may predict the development of photo-induced and non-photo-induced drug eruptions.
A cohort of 40 patients with drug eruptions, 10 of whom had developed a photo-induced drug reaction, and matched controls (116 for GSTM1 and GSTT1, 120 for GSTP1) were studied. Genotyping was conducted using direct sequencing and polymerase chain reaction.
The GSTP1 Val/Val genotype was significantly associated with non-photosensitive drug eruptions (OR = 3.64, P value = 0.038), whereas associations observed between GSTP1, GSTM1, GSTT1 polymorphisms and photosensitive drug eruptions did not reach statistical significance.
Variations in GSTP1 may affect the risk to develop non-photo-induced drug eruptions. These results warrant confirmatory studies in a larger patient sample.
谷胱甘肽 S-转移酶（GSTs）在细胞对抗氧化损伤的保护中起着至关重要的作用。已经描述了三个主要 GST 基因座中的多态性。许多研究都在寻找 GSTs 与皮肤疾病之间的关联。
确定 GSTM1、GSTT1 和 GSTP1 基因中的多态性是否可能预测光诱导和非光诱导药物疹的发生。
对 40 例药物疹患者（其中 10 例发生光诱导药物反应）和匹配对照者（GSTM1 和 GSTT1 为 116 例，GSTP1 为 120 例）进行了研究。采用直接测序和聚合酶链反应进行基因分型。
GSTP1 Val/Val 基因型与非光敏感药物疹显著相关（OR=3.64，P 值=0.038），而 GSTP1、GSTM1、GSTT1 多态性与光敏感药物疹之间的关联未达到统计学意义。
GSTP1 的变异可能影响非光诱导药物疹的发病风险。这些结果需要在更大的患者样本中进行验证性研究。
